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Séminaire – Stephanie Borgland

vendredi 5 juillet 2019 / 11:00 - 12:00

Diet induced plasticity in the orbitofrontal cortex: implications for overeating

Lieu : Centre Broca Nouvelle-Aquitaine


Dr. Stephanie Borgland
Associate Professor,
The Hochkiss Brain Institute,
Calgary, Canada

Invitée par Guillaume Ferreira
Nutrineuro


Abstract

The orbitofrontal cortex (OFC) receives sensory information about food and integrates these signals with expected outcomes. Thus, the OFC registers the current value of foods and updates actions based on this information. OFC lesions in animals show a lack of food devaluation. Interestingly, obese humans and rats fed a cafeteria diet have impaired devaluation of food rewards, implicating a potential obesity-induced dysfunction the OFC. We will present findings demonstrating that long-term exposure to a palatable diet alters astrocyte modulation of glutamate homeostasis within the OFC, resulting in enhanced endocannabinoid signalling and tone via Group 1 mGluR activation, which then leads to decreased GABAergic synaptic transmission. We will also present data showing impaired reward devaluation in obese rodents and that this can be restored by increasing GABAergic tone in the OFC.  Together these results suggest that obesogenic diets disrupt synaptic transmission in the OFC, which may influence cognitive and emotional processing of decision-making in obesity.

Recent publications

Naef L, Seabrook L, Hsiao J, Li C, Borgland SL (2019). Insulin in the ventral tegmental area reduces cocaine-evoked dopamine in the nucleus accumbens in vivo. Eur J Neurosci. in press

Balsevich G, Sticht M, Bowles NP, Singh A, Lee TTY, Li Z, Chelikani PK, Lee FS, Borgland SL, Hillard CJ, McEwen BS, Hill MN (2018). Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. Proc Natl Acad Sci U S A. 115(29):7605-7610.

Mills F, Globa AK, Liu S, Cowan CM, Mobasser M, Phillips AG, Borgland SL, Bamji SX (2017). Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning. Nat Neurosci. 20(4):540-549.

Baimel C, Lau BK, Qiao M, Borgland SL (2017). Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons. Cell Rep. 18(6):1346-1355.

Thompson JL, Drysdale M, Baimel C, Kaur M, MacGowan T, Pitman KA, Borgland SL (2017). Obesity-Induced Structural and Neuronal Plasticity in the Lateral Orbitofrontal Cortex. Neuropsychopharmacology 42(7):1480-1490.

Liu S, Globa AK, Mills F, Naef L, Qiao M, Bamji SX, Borgland SL (2016). Consumption of palatable food primes food approach behavior by rapidly increasing synaptic density in the VTA. Proc Natl Acad Sci U S A. 113(9):2520-5.

Thompson JL, Yang J, Lau B, Liu S, Baimel C, Kerr LE, Liu F, Borgland SL (2016). Age-Dependent D1-D2 Receptor Coactivation in the Lateral Orbitofrontal Cortex Potentiates NMDA Receptors and Facilitates Cognitive Flexibility. Cereb Cortex. 26(12):4524-4539.

Baimel C, Borgland SL (2015). Orexin Signaling in the VTA Gates Morphine-Induced Synaptic Plasticity. J Neurosci. 35(18):7295-303


Prochainement

  1. Conférence mensuelle (PhD seminar series) – Laurent Bourdieu

    vendredi 6 septembre 2019 / 11:30

    Fast 3D imaging of neuronal activity in visual cortex across multiple layers in awake mice

  2. Cajal lectures : Whole brain imaging

    lundi 9 septembre 2019 - vendredi 27 septembre 2019

    Free entrance lectures / Venue: CGFB

  3. Séminaire – Francisco Papaleo

    vendredi 13 septembre 2019 / 11:30

    Bottom-Up and Top-Down Control of Emotion Recognition.

  4. LabEx TRAIL scientific day

    lundi 16 septembre 2019 / 14:00 - 18:00

    Dedicated to brain connectivity.

  5. Journée Synapse

    mardi 17 septembre 2019

    Centre Broca Nouvelle-Aquitaine


Conférence internationale : REWARD

Du 2 au 4 octobre

L’événement en un coup d’oeil :
télécharger le livret (programme,
inscription, soumission d’abstract…)

brainconf.u-bordeaux.fr

Détails

Date :
vendredi 5 juillet 2019
Heure :
11:00 - 12:00
Catégorie d’Évènement: