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Séminaire impromptu – Louise Parr-Brownlie

lundi 6 mai 2019 / 09:30

Lieu : CGFB – Salle de conférence

Louise Parr-Brownlie
Départements d’anatomie, Centre de recherche sur la santé cérébrale,
Brain Research New Zealand, Université d’Otago, Dunedin

Invitée par Clémentine Bosch-Bouju – Nutrineuro

Abstract :

Parkinson’s disease is a movement disorder that affects 0.2% of people over 60 years of age. Drug treatments are effective initially but cause dyskinesias in 80% of patients. Deep brain stimulation is an adjunct treatment, but also causes side effects such as depression. Novel treatments are needed to improve the quality of life and independence for patients. To address this, we have been exploring structural and pathophysiological in the basal ganglia-thalamocortical pathway in the 6-hydroxydopamine (6-OHDA) hemi-parkinsonian lesioned model. We have found that boutons in ventroanterior (VA) motor thalamus that arose from neurons with somata in a basal ganglia output nucleus (substantia nigra pars reticulata, SNpr) were smaller and had fewer synapses in 6-OHDA lesioned compared to sham rats. Resting and movement-related activity of VA neurons were altered in parkinsonian rats. To test if VA activity controls movements, we optogenetically stimulated acute parkinsonian rats using the timing of typical VA spiking activity from sham rats and found that reaching was restored in parkinsonian rats. Our data show that motor thalamus activity controls movements. In addition, despite structural changes of basal ganglia input to motor thalamus in parkinsonian rats, stimulating VA neurons with complex patterns may treat movement deficits.

Prochainement

  1. Soutenance de thèse – Dylan Pommier

    jeudi 20 juin 2019 / 14:30

    "L’astrocyte, intégrateur et régulateur de l’activité synaptique excitatrice dans des conditions physiologiques et pathologiques"

  2. Séminaire – David Stellwagen

    jeudi 20 juin 2019 / 15:30

    TNF-mediated synaptic plasticity in the response to stress and reward

  3. Séminaire – André Ramos

    vendredi 21 juin 2019 / 11:30

    The long (and uncertain) way from anxiety-related behaviors to genes

  4. Séminaire – Manojkumar Saranathan

    vendredi 21 juin 2019 / 14:30

    Segmentation of thalamic nuclei from 3T MRI with applications

  5. Soutenance de thèse – Sandra Dubes

    lundi 24 juin 2019 / 14:30

    Rôle du microARN miR-124 dans la plasticité homéostatique via le contrôle de l’expression de la synaptopodine et des récepteurs AMPA dans les neurones de l'hippocampe.

Détails

Date :
lundi 6 mai 2019
Heure :
09:30
Catégorie d’Évènement: