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Séminaire – Henning Fenselau

16 novembre 2018 / 11:30 - 12:30

Abstract :

Multiple distinct neuronal cell populations distributed throughout the central nervous system tightly coordinate energy and glucose homeostasis. This is achieved by precise synaptic mechanisms that operate within these neuronal circuits. The aim of our research is to elucidate synaptic connectivity and synaptic adaptions – such as long-term potentiation – at defined synapses within the neuronal circuits regulating behaviors such as feeding, drinking, and sexual behavior as well as glucose homeostasis. The overall goal is to provide a connectivity map of the brain regulating these vital functions and correlate synaptic adaptions with physiologic functions. To address these questions, we employ a wide range of methodologies including in vivo opto-and chemogenetics, brain slice electrophysiology as well as transgenic knockin and knockout mice. The combination of these approaches allows us to study neurotransmitters, synaptic plasticity, and activity patterns in defined circuit elements and enable us to understand how synaptic functions within these neural circuits could become dysregulated in conditions such as obesity or diabetes.

Selected publications

Fenselau H*, Campbell JN*, Verstegen AM*, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB. A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH. Nat Neurosci. 2017 Jan;20(1):42-51. (*Equal contribution)

Resch JM*, Fenselau H*, Madara JC*, Wu C, Campbell JN, Lyubetskaya A, Dawes BA, Tsai LT, Li MM, Livneh Y, Ke Q, Kang PM, Fejes-Tóth G, Náray-Fejes-Tóth A, Geerling JC, Lowell BB. Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Neuron. 2017 Sep 27;96(1):190-206.e7. (*Equal contribution)

Todd WD*, Fenselau H*, Wang JL, Zhang R, Machado NL, Venner A, Broadhurst RY, Kaur S, Lynagh T, Olson DP, Lowell BB, Fuller PM, Saper CB. A hypothalamic circuit for the circadian control of aggression. Nat Neurosci. 2018 May;21(5):717-724. (*Equal contribution)

Prochainement

  1. Séminaire – David Stellwagen

    jeudi 20 juin 2019 / 15:30

    TNF-mediated synaptic plasticity in the response to stress and reward

  2. Séminaire – André Ramos

    vendredi 21 juin 2019 / 11:30

    The long (and uncertain) way from anxiety-related behaviors to genes

  3. Séminaire – Manojkumar Saranathan

    vendredi 21 juin 2019 / 14:30

    Segmentation of thalamic nuclei from 3T MRI with applications

  4. Cajal course : Biosensors and actuators for cellular and systems neuroscience

    dimanche 23 juin 2019 - samedi 13 juillet 2019

    Les séminaires sont ouverts à tous.

  5. Soutenance de thèse – Sandra Dubes

    lundi 24 juin 2019 / 14:30

    Rôle du microARN miR-124 dans la plasticité homéostatique via le contrôle de l’expression de la synaptopodine et des récepteurs AMPA dans les neurones de l'hippocampe.

Détails

Date :
16 novembre 2018
Heure :
11:30 - 12:30
Catégorie d’Évènement: