16 nov. 2018 à 11:30
Multiple distinct neuronal cell populations distributed throughout the central nervous system tightly coordinate energy and glucose homeostasis. This is achieved by precise synaptic mechanisms that operate within these neuronal circuits. The aim of our research is to elucidate synaptic connectivity and synaptic adaptions – such as long-term potentiation – at defined synapses within the neuronal circuits regulating behaviors such as feeding, drinking, and sexual behavior as well as glucose homeostasis. The overall goal is to provide a connectivity map of the brain regulating these vital functions and correlate synaptic adaptions with physiologic functions. To address these questions, we employ a wide range of methodologies including in vivo opto-and chemogenetics, brain slice electrophysiology as well as transgenic knockin and knockout mice. The combination of these approaches allows us to study neurotransmitters, synaptic plasticity, and activity patterns in defined circuit elements and enable us to understand how synaptic functions within these neural circuits could become dysregulated in conditions such as obesity or diabetes.
Fenselau H*, Campbell JN*, Verstegen AM*, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB. A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH. Nat Neurosci. 2017 Jan;20(1):42-51. (*Equal contribution)
Resch JM*, Fenselau H*, Madara JC*, Wu C, Campbell JN, Lyubetskaya A, Dawes BA, Tsai LT, Li MM, Livneh Y, Ke Q, Kang PM, Fejes-Tóth G, Náray-Fejes-Tóth A, Geerling JC, Lowell BB. Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Neuron. 2017 Sep 27;96(1):190-206.e7. (*Equal contribution)
Todd WD*, Fenselau H*, Wang JL, Zhang R, Machado NL, Venner A, Broadhurst RY, Kaur S, Lynagh T, Olson DP, Lowell BB, Fuller PM, Saper CB. A hypothalamic circuit for the circadian control of aggression. Nat Neurosci. 2018 May;21(5):717-724. (*Equal contribution)