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Séminaire – Charles Nicholson

vendredi 15 mars 2019 / 11:30 - 12:30

Exploring Brain Extracellular Space through Analysis of Diffusion

 

Abstract

Brain extracellular space (ECS) is the narrow microenvironment that surrounds every cell of the central nervous system. Attempts to reveal the size and structure of the ECS using electron microscopy have had limited success; however, a biophysical approach based on diffusion of selected probe molecules over distances of 10 – 100 micrometers has proved useful. This approach has shown that the ECS occupies approximately 20% of brain tissue and small molecules have an effective diffusion coefficient that is two-fifths that in a free solution. Monte Carlo modeling indicates that geometrical constraints, including dead-space microdomains, contribute to the hindrance to diffusion. Imaging the spread of macromolecules shows them increasingly hindered as a function of size and suggests that the gaps between cells are predominantly approximately 40 nanometers with wider local voids that may represent dead-spaces. Diffusion measurements also characterize interactions of substances with the extracellular matrix. it appears that the size of the ECS changes in going from the sleeping to waking state and this may have implications for the removal of waste substances from the brain as a component of the glymphatic system.

Prochainement

  1. Séminaire – Suzana Herculano-Houzel

    vendredi 26 avril 2019 / 11:30

    Life slows down with more neurons in the cerebral cortex

  2. Ciné-débat : « La peur, cette séduisante sensation… »

    mardi 30 avril 2019 / 18:30

    Projection du film "Le Silence des agneaux" suivie d'un débat.

  3. Séminaire impromptu – Maxime Assous

    vendredi 3 mai 2019 / 10:00 - 11:30

    Extrinsic innervation of striatal interneurons and implications for the local microcircuitry.

  4. Conférence mensuelle – Richard Robitaille

    vendredi 3 mai 2019 / 11:30 - 12:30

    Regulation of synaptic structure ad function by glial cells in health and disease

  5. Séminaire – Stéphanie Trouche

    vendredi 10 mai 2019 / 11:30 - 12:30

    Invitant : Catherine Le Moine

Détails

Date :
vendredi 15 mars 2019
Heure :
11:30 - 12:30
Catégorie d’Évènement:

Lieu

Centre Broca Nouvelle-Aquitaine
38 Rue Albert Marquet
Bordeaux, 33000 France
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