Séminaire de Bioinformatique et Biologie Computationnelle sur la thématique d’analyse de diversité génétique de population virale (virus de l’huître).
Organisé par le CBiB.
Orateur : Jean Delmotte, IHPE, Université de Montpellier
TITRE : Phylogeography, genetic diversity and connectivity of Ostreid herpesvirus-1 population in France
Lien visio : https://u-bordeaux-fr.zoom.us/j/9307673780
Recurrent mortalities have been affecting juvenile Pacific oysters (Crassostrea gigas) for more than 30 years. Among the pathogens involved, the preponderant role of the Ostreid herpesvirus 1 (OsHV-1) virus in the mortality syndrome called “Pacific Oyster Mortality Syndrome” (POMS) has recently been demonstrated. The OsHV-1 epidemics in oyster farming areas have made this virus a major threat to the oyster industry. However, genomic epidemiology in certain regions at risk, in particular in France, remains limited. We report 21 OsHV-1 genomes generated using high-throughput sequencing during mass mortality episodes in 3 regions of the French coast. Using new bioinformatics methodology and adopting a three-set genomic variation analysis strategy, we reveal the connectivity of OsHV-1 viral population in France. The main source is probably the Marennes d’Oléron area, the viruses are then introduced into other shellfish-growing areas, probably following the transfer of oyster spat. The spatial heterogeneity of the transmission of OsHV-1 calls into question the surveillance of malacoherpesviruses and disease control measures.