The long (and uncertain) way from anxiety-related behaviors to genes
When: June 21st, 2019
Professor dept Cell Biology, Embryology & Genetics,
University Federal Santa Catarina, Florianopolis, Brasil
Title: The long (and uncertain) way from anxiety-related behaviors to genes
Starting with a seminal work where we have mapped the first genomic region controlling fear-related behaviors in rats, our team developed a long-term strategy that aimed at identifying the molecular bases of anxiety-related traits and disorders. After constructing a new genetic model of anxiety (the SLA16 rat strain), its behavioral and neurobiological characterization, coupled with gene expression studies and genome sequencing, revealed a far more complex scenario, which opened new avenues to investigate a variety of processes, including learning, attention deficit and hyperactivity.
200 Citations each and/or >12 Impact-Factor journals
RAMOS, A.; BERTON, O. ; MORMÈDE, P. ; CHAOULOFF, F. A multiple-test study of anxiety-related behaviours in six inbred rat strains. Behavioural Brain Research, 85, 57-69, 1997.
RAMOS, A.; MORMÈDE, P. Stress and emotionality: a multidimensional and genetic approach. Neuroscience and Biobehavioral Reviews, 22, 33-57, 1998.
RAMOS, A.; MOISAN, M.-P. ; CHAOULOFF, F. ; MORMÈDE, C. ; MORMÈDE, P. Identification of female-specific QTLs affecting an emotionality-related behavior in rats. Molecular Psychiatry, 4, 453-462, 1999.
RAMOS, A. Animal models of anxiety: do I need multiple tests? Trends in Pharmacological Sciences, 29, 493-498, 2008.
CHIAVEGATTO, S. ; IZÍDIO, G.S. ; MENDES-LANA, A. ; ANEAS, I. ; FREITAS, T. A. ; TORRAO, A.S. ; CONCEICAO, I.M. ; BRITTO, L.R.G. ; RAMOS, A. . Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety. Molecular Psychiatry, 14, 894-905, 2009.
RAMOS, A.; RAZZERA, G. Education: Funding plea for rural lab outreach. Nature, 515, 198 – 198, 2014.
RAMOS, A. Science popularization: Research videos in indigenous languages. Nature, 551, 168 – 168, 2017.
Innovative models and/or papers with high relevance for this talk
RAMOS, A.; PEREIRA, E. ; MARTINS, G. C. ; WEHRMEISTER, T. D. ; IZÍDIO, G.S. Integrating the open field, elevated plus maze and light/dark box to assess different types of emotional behaviors in one single trial. Behavioural Brain Research, 193, 277-288, 2008.
FRASER, L.M. ; BROWN, R.E. ; HUSSIN, A. ; FONTANA, M. ; WHITTAKER, A. ; O LEARY, T.P. ; LEDERLE, L. ; HOLMES, A. ; RAMOS, A. Measuring anxiety- and locomotion-related behaviours in mice: a new way of using old tests. Psychopharmacology, 211, 99-112, 2010.
MEDEIROS, G. F. ; PEREIRA, E. ; N. GRANZOTTO ; RAMOS, A. Low-anxiety rat phenotypes can be further reduced through genetic intervention. Plos One, 8, 12, 83666, 2013.
*MEDEIROS, G.F. ; CORRÊA, F.J. ; CORVINO, M.E. ; IZÍDIO, G. S.; RAMOS, A. The long way from complex phenotypes to genes: the story of rat chromosome 4 and its behavioral effects. World Journal of Neuroscience, 04, 203-215, 2014.
**ANSELMI, M. ; CORREA,F.J. ; SANTOS, J.R. ; SILVA , A.F. ; CUNHA, J.A. ; LEÃO, A.H. ; CAMPELO, C.L. ; RIBEIRO, A.M. ; SILVA, R.H. ; IZÍDIO, G.S. Genetic evidence for chromosome 4 loci influencing learning and memory. Neurobiology of Learning and Memory. 131:182-91, 2016.
PERTILE, R.A.N. ; CORVINO, M.E. ; MARCHETTE, R.C N. ; PAVESI, E. ; CAVALLI, J. ; RAMOS, A. ; IZÍDIO, G.S. The quinpirole hypolocomotive effects are strain and route of administration dependent in SHR and SLA16 isogenic rats. Behavior Genetics, 47, 5, 552–561, 2017.
*cover of the issue
**speaker is not an author but the work is from his lab
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