Chargement Évènements

« Tous les Évènements

  • Cet évènement est passé

Séminaire – André Ramos

vendredi 21 juin 2019 / 11:30

The long (and uncertain) way from anxiety-related behaviors to genes

Lieu: Centre Broca Nouvelle-Aquitaine

André RAMOS
Professor dept Cell Biology, Embryology & Genetics,
University Federal Santa Catarina, Florianopolis, Brasil

Invited by Marie-Pierre Moisan
Nutrineuro

Abstract

Starting with a seminal work where we have mapped the first genomic region controlling fear-related behaviors in rats, our team developed a long-term strategy that aimed at identifying the molecular bases of anxiety-related traits and disorders. After constructing a new genetic model of anxiety (the SLA16 rat strain), its behavioral and neurobiological characterization, coupled with gene expression studies and genome sequencing, revealed a far more complex scenario, which opened new avenues to investigate a variety of processes, including learning, attention deficit and hyperactivity.

Selected publications

200 Citations each and/or >12 Impact-Factor journals

RAMOS, A.; BERTON, O. ; MORMÈDE, P. ; CHAOULOFF, F. A multiple-test study of anxiety-related behaviours in six inbred rat strains. Behavioural Brain Research, 85, 57-69, 1997.

RAMOS, A.; MORMÈDE, P. Stress and emotionality: a multidimensional and genetic approach. Neuroscience and Biobehavioral Reviews, 22, 33-57, 1998.

RAMOS, A.; MOISAN, M.-P. ; CHAOULOFF, F. ; MORMÈDE, C. ; MORMÈDE, P. Identification of female-specific QTLs affecting an emotionality-related behavior in rats. Molecular Psychiatry, 4, 453-462, 1999.

RAMOS, A. Animal models of anxiety: do I need multiple tests? Trends in Pharmacological Sciences, 29, 493-498, 2008.

CHIAVEGATTO, S. ; IZÍDIO, G.S. ; MENDES-LANA, A. ; ANEAS, I. ; FREITAS, T. A. ; TORRAO, A.S. ; CONCEICAO, I.M. ; BRITTO, L.R.G. ; RAMOS, A. . Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety. Molecular Psychiatry, 14, 894-905, 2009.

RAMOS, A.; RAZZERA, G. Education: Funding plea for rural lab outreach. Nature, 515, 198 – 198, 2014.

RAMOS, A. Science popularization: Research videos in indigenous languages. Nature, 551, 168 – 168, 2017.

 

Innovative models and/or papers with high relevance for this talk

RAMOS, A.; PEREIRA, E. ; MARTINS, G. C. ; WEHRMEISTER, T. D. ; IZÍDIO, G.S. Integrating the open field, elevated plus maze and light/dark box to assess different types of emotional behaviors in one single trial. Behavioural Brain Research, 193, 277-288, 2008.

FRASER, L.M. ; BROWN, R.E. ; HUSSIN, A. ; FONTANA, M. ; WHITTAKER, A. ; O LEARY, T.P. ; LEDERLE, L. ; HOLMES, A. ; RAMOS, A. Measuring anxiety- and locomotion-related behaviours in mice: a new way of using old tests. Psychopharmacology, 211, 99-112, 2010.

MEDEIROS, G. F. ; PEREIRA, E. ; N. GRANZOTTO ; RAMOS, A. Low-anxiety rat phenotypes can be further reduced through genetic intervention. Plos One, 8, 12, 83666, 2013.

*MEDEIROS, G.F. ; CORRÊA, F.J. ; CORVINO, M.E. ; IZÍDIO, G. S.; RAMOS, A. The long way from complex phenotypes to genes: the story of rat chromosome 4 and its behavioral effects. World Journal of Neuroscience, 04, 203-215, 2014.

**ANSELMI, M. ; CORREA,F.J. ; SANTOS, J.R. ; SILVA , A.F. ; CUNHA,  J.A. ; LEÃO,  A.H. ; CAMPELO, C.L. ; RIBEIRO, A.M. ; SILVA, R.H. ; IZÍDIO, G.S. Genetic evidence for chromosome 4 loci influencing learning and memory. Neurobiology of Learning and Memory. 131:182-91, 2016.

PERTILE, R.A.N. ; CORVINO, M.E. ; MARCHETTE, R.C N. ; PAVESI, E. ; CAVALLI, J. ; RAMOS, A. ; IZÍDIO, G.S. The quinpirole hypolocomotive effects are strain and route of administration dependent in SHR and SLA16 isogenic rats. Behavior Genetics, 47, 5, 552–561, 2017.

*cover of the issue

**speaker is not an author but the work is from his lab


Seminar supported by Bordeaux Neurocampus 

Prochainement

  1. Conférence mensuelle (PhD seminar series) – Laurent Bourdieu

    vendredi 6 septembre 2019 / 11:30

    Fast 3D imaging of neuronal activity in visual cortex across multiple layers in awake mice

  2. Cajal lectures : Whole brain imaging

    lundi 9 septembre 2019 - vendredi 27 septembre 2019

    Free entrance lectures / Venue: CGFB

  3. Séminaire – Francisco Papaleo

    vendredi 13 septembre 2019 / 11:30

    Bottom-Up and Top-Down Control of Emotion Recognition.

  4. LabEx TRAIL scientific day

    lundi 16 septembre 2019 / 14:00 - 18:00

    Dedicated to brain connectivity.

  5. Journée Synapse

    mardi 17 septembre 2019

    Centre Broca Nouvelle-Aquitaine


Conférence internationale : REWARD

Du 2 au 4 octobre

L’événement en un coup d’oeil :
télécharger le livret (programme,
inscription, soumission d’abstract…)

brainconf.u-bordeaux.fr

Détails

Date :
vendredi 21 juin 2019
Heure :
11:30
Catégorie d’Évènement: