Venue: Centre Broca Nouvelle-Aquitaine
Jocelyne BLOCH (CHUV – CH) and Grégoire COURTINE (EPFL, CH)
.NeuroRestore | Defitech Center for Interventional Neurotherapies, Switzerland
Neuro-X Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland
Department of Neurosurgery, Lausanne University Hospital (CHUV) , Lausanne, Switzerland
Faculty of Biology and Medicine, University of Lausanne (Unil), Lausanne, Switzerland
Invited by Zoé Grivet (Benazzouz and Fossat’s team – IMN)
Implanted systems to regulate neurological functions
We have combined our respective expertise in neurosurgery, neurology, neuroscience and neuro-engineering to establish a research and treatment center called .NeuroRestore. This center develops neurotherapies requiring neurosurgical interventions to regulate or restore neurological functions following neurotrauma and neurodegenerative diseases. .NeuroRestore combines cutting-edge basic, translational and clinical research platforms that enable synergia between discoveries, innovations and real-world applications. During our talk, we will present several examples of these unconventional developments, including the design and validation of neuroprosthetic systems that reversed paralysis in people with spinal cord injury, reestablished hemodynamic stability in people suffering from orthostatic hypotension, and alleviated gait deficits due to Parkinson’s disease.
Jocelyne Bloch is neurosurgeon and Professor of neurological medicine at the University Hospital Lausanne (CHUV) where she leads the functional neurosurgery unit. G. Courtine is Professor of neuroscience at the Swiss Federal Institute of Technology Lausanne (EPFL). They cofounded .NeuroRestore, a center dedicated to the development of neurotherapies involving neurosurgical interventions. They are known worldwide for the conception of neuroprosthetic implants that restored walking in people with chronic paralysis. They also cofounded ONWARD medical; a start-up that aim to translate their discoveries into medical products.
- The neurons that restore walking after paralysis. Nature, 2023.
- Implanted System for Orthostatic Hypotension in Multiple-System Atrophy New England Journal of Medicine 2022
- Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis. Nature Medicine 2022
- Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury. Nature 2021
- Targeted neurotechnology restores walking in humans with spinal cord injury. Nature. 2018
- Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature. 2018
- A brain-spine interface alleviating gait deficits after spinal cord injury in primates. Nature. 2016
- Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury. Nature Medicine.
- Electronic dura mater for long-term multimodal neural interfaces. Science. 2015
- Restoring voluntary control of locomotion after paralyzing spinal cord injury. Science. 2012
PhD seminars are organized by the NBA, Bordeaux Neurocampus, and the Bordeaux Neurocampus Graduate Program