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Conférence mensuelle – Richard Robitaille

vendredi 3 mai 2019 / 11:30 - 12:30

Regulation of synaptic structure ad function by glial cells in health and disease

Lieu : Centre Broca Nouvelle-Aquitaine / Salle de conférence


Invité par Bordeaux Neurocampus.
Dans le cadre des PhD seminar series

Richard Robitaille
Professeur titulaire
Université de Montréal
https://neurosciences.umontreal.ca/recherche/les-chercheurs/richard-robitaille/

 


Abstract

My research focuses on the role of glial cells in the regulation of synaptic functions in normal as well as in pathological conditions. We use mammalian neuromuscular junctions and acute brain slices as experimental models to address the role of glial cells in the regulation of synaptic transmission and plasticity, and the contribution of glial cells in the outcome of synaptic competition, during aging and in amyotrophic lateral sclerosis (ALS).  I will address two different aspects in my talk. First, I will present our recent work on the roles of astrocytes in the regulation on inhibitory interneurons in the hippocampus and discuss the possible implication for the hippocampal network. Then, I will discuss some of our work at the neuromuscular junction in ALS and highlight ex vivo and in vivo experiments to illustrate that neuromuscular changes are precocious, with a strong influence of the local environment in the outcome of NMJ denervation in ALS.

Publications choisies

  • Robitaille, R. (1998).  Modulation of synaptic efficacy and synaptic depression by glial cells at the frog neuromuscular junction.  Neuron. 21, 847-855.
  • Serrano, A., Haddjeri, N., Lacaille, J.C. and Robitaille, R. (2006) GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression.  Journal of Neuroscience 26, 5370-5382.
  • Panatier, A., Haber, M., Murai, K.K., Lacaille, J.C. and Robitaille, R. (2011) Astrocytes are constitutive regulators of basal transmission at single CNS synapses. Cell, 146, 785 – 798.
  • Darabid, H. Arbour, D. and Robitaille R. (2013) Glial cells decipher synaptic competition at the mammalian neuromuscular junction.  Journal of Neuroscience, 33(4):1297-313.
  • Araque, A., Carmignoto, G., Haydon, P.G., Oliet, S., Robitaille, R. and Volterra, A. (2014) Gliotransmitters Travel in Time and Space. Neuron, 81(4):728-739.
  •  Darabid, H., Perez, A. and Robitaille, R. (2014) Neuromuscular synaptogenesis: Coordinating several partners with multiple functions. Nature Reviews Neuroscience, 15, 703 – 718.
  • Arbour, A., Tremblay, E., Martineau, E., Julien, J.P. and Robitaille, R. (2015) Early and persistent abnormal decoding by glial cells at the neuromuscular junction in an ALS mouse model. Journal of Neuroscience, 35(2):688 –706.

Prochainement

  1. Séminaire – David Stellwagen

    jeudi 20 juin 2019 / 15:30

    TNF-mediated synaptic plasticity in the response to stress and reward

  2. Séminaire – André Ramos

    vendredi 21 juin 2019 / 11:30

    The long (and uncertain) way from anxiety-related behaviors to genes

  3. Séminaire – Manojkumar Saranathan

    vendredi 21 juin 2019 / 14:30

    Segmentation of thalamic nuclei from 3T MRI with applications

  4. Soutenance de thèse – Sandra Dubes

    lundi 24 juin 2019 / 14:30

    Rôle du microARN miR-124 dans la plasticité homéostatique via le contrôle de l’expression de la synaptopodine et des récepteurs AMPA dans les neurones de l'hippocampe.

  5. Cajal course : Biosensors and actuators for cellular and systems neuroscience

    mardi 25 juin 2019 - mardi 9 juillet 2019

    Les séminaires sont ouverts à tous.

Détails

Date :
vendredi 3 mai 2019
Heure :
11:30 - 12:30
Catégorie d’Évènement: