Organization and adaptability of motor systems
By combining behavioral analysis with electrophysiology, dynamic clamp, functional imaging, and neuroanatomy technology, our team’s overall research objective is to decipher the neuronal basis of the short- and long-term functional plasticity of motor systems, with the principal experimental goal of trying to relate cellular, synaptic and neural network physiology to particular aspects of adaptive behaviors. Using three complementary animal models, from invertebrate to mammal, we analyze the intimate interactions between intrinsic and neuromodulatory processes in shaping either spontaneous or sensory-evoked motor programs, and controlling their lifespan adaptations.
Mots clés
Assemblées neuronales, Codage et intégration du signal, Connectivité, Développement du système nerveux, Excitabilité neuronale, Formation et fonctionnement des circuits neuronaux, Motricité, Mouvement, Neurophysiologie, Optogénétique, Physiologie synaptique, Plasticité des réseaux, Plasticité synaptique, Système auditif et d’équilibrationSelected publications
- Acute exposure to zinc oxide nanoparticles critically disrupts operation of the respiratory neural network in neonatal rat.. Nicolosi A, Cardoit L, Pasquereau P, Jaillet C, Thoby-Brisson M, Juvin L, Morin D. NeuroToxicology. 2018-07. 67 (150-160)
- Functional organization of vestibulospinal inputs on thoracic motoneurons responsible for trunk postural control in Xenopus. Anne Olechowski‐Bessaguet, Raphaël Grandemange, Laura Cardoit, Elric Courty,François M. Lambert, Didier Le Ray. J Physiol.. 2020-02-03. 598 (4) : 817-838.
- Modulation of respiratory network activity by forelimb and hindlimb locomotor generators. Jean‐Patrick Le Gal, Eloïse Colnot, Laura Cardoit, Julien Bacqué Cazenave, Muriel Thoby‐Brisson, Laurent Juvin, Didier Morin. Eur J Neurosci. 2020-03-09.
- Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus. Francois M Lambert, Laura Cardoit, Elric Courty, Marion Bougerol, Muriel Thoby-Brisson, John Simmers, Hervé Tostivint, Didier Le Ray. eLife. 2018-05-30. 7
- Alteration of size perception: serotonin has opposite effects on the aggressiveness of crayfish confronting either a smaller or a larger rival.. Julien Bacqué-Cazenave, Daniel Cattaert, Jean Paul Delbecque, Pascal Fossat. J Exp Biol. 2018-04-26. 221 (12) : jeb177840.
- Role of the K+-Cl– Cotransporter KCC2a Isoform in Mammalian Respiration at Birth. Christophe J. Dubois, Laura Cardoit, Veronika Schwarz, Marika Markkanen, Matti S. Airaksinen, Pavel Uvarov, John Simmers, Muriel Thoby-Brisson. eNeuro. 2018-01-01. 5 (5) : ENEURO.0264-18.2018.
- Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis inXenopus. Francois M. Lambert, Laura Cardoit, Elric Courty, Marion Bougerol, Muriel Thoby-Brisson, John Simmers, Hervé Tostivint, Didier Le Ray. . 2017-08-08.
- Social harassment induces anxiety-like behaviour in crayfish.. Julien Bacqué-Cazenave, Daniel Cattaert, Jean-Paul Delbecque, Pascal Fossat. Sci Rep. 2017-01-03. 7 (1)
- Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network. Marc Chevalier, Natalia Toporikova, John Simmers, Muriel Thoby-Brisson. eLife. 2016-07-19. 5
- Functional magnetic resonance microscopy at single-cell resolution in Aplysia californica.. G. Radecki, R. Nargeot, I. O. Jelescu, D. Le Bihan, L. Ciobanu. Proceedings of the National Academy of Sciences. 2014-05-28. 111 (23) : 8667-8672.
- Differential roles of nonsynaptic and synaptic plasticity in operant reward learning-induced compulsive behavior.. Fred Sieling, Alexis Bédécarrats, John Simmers, Astrid A. Prinz, Romuald Nargeot. Current Biology. 2014-05-01. 24 (9) : 941-950.
- Highlighting manganese dynamics in the nervous system of Aplysia californica using MEMRI at ultra-high field.. Ileana O. Jelescu, Romuald Nargeot, Denis Le Bihan, Luisa Ciobanu. NeuroImage. 2013-08-01. 76 : 264-271.
- Implication of dopaminergic modulation in operant reward learning and the induction of compulsive-like feeding behavior in Aplysia.. A. Bedecarrats, C. Cornet, J. Simmers, R. Nargeot. Learning & Memory. 2013-05-16. 20 (6) : 318-327.
- Functional organization and adaptability of a decision-making network in aplysia.. Romuald Nargeot, John Simmers. Front. Neurosci.. 2012-01-01. 6
- Neural mechanisms of operant conditioning and learning-induced behavioral plasticity in Aplysia.. Romuald Nargeot, John Simmers. Cell. Mol. Life Sci.. 2010-11-02. 68 (5) : 803-816.
- Changes in electrical coupling via dynamic clamp produces correlates of operant conditioning in the feeding CPG networks of Aplysia.. Fred H Sieling, John Simmers, Astrid A Prinz, Romuald Nargeot. BMC Neuroscience. 2010-01-01. 11 (Suppl 1) : P1.
- Cellular and network mechanisms of operant learning-induced compulsive behavior in Aplysia.. Romuald Nargeot, Morgane Le Bon-Jego, John Simmers. Current Biology. 2009-06-01. 19 (12) : 975-984.
- Behavioral and in vitro correlates of compulsive-like food seeking induced by operant conditioning in Aplysia.. R. Nargeot, C. Petrissans, J. Simmers. Journal of Neuroscience. 2007-07-25. 27 (30) : 8059-8070.
- Correlation between activity in neuron B52 and two features of fictive feeding in Aplysia.. Romuald Nargeot, Douglas A Baxter, John H Byrne. Neuroscience Letters. 2002-08-01. 328 (2) : 85-88.
- Sensory-induced plasticity of motor pattern selection in the lobster stomatogastric nervous system.. R. Nargeot, M. Moulins. European Journal of Neuroscience. 1997-08-01. 9 (8) : 1636-1645.
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Didier Le Ray
Le Ray
(Researcher)
John Simmers Simmers (Researcher)
Olivier Brissaud Brissaud (Hospital practitioner)
Denis Combes Combes (University Teacher- Researcher)
François Lambert Lambert (Researcher)
Romuald Nargeot Nargeot (University Teacher- Researcher)
John Simmers Simmers (Researcher)
Olivier Brissaud Brissaud (Hospital practitioner)
Denis Combes Combes (University Teacher- Researcher)
François Lambert Lambert (Researcher)
Romuald Nargeot Nargeot (University Teacher- Researcher)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Julien Bacqué-Cazenave
Bacqué-Cazenave
Doctorant(s)
Anne Olechowski
Olechowski
Gabriel Pitollat Pitollat
Gabriel Barrios Barrios
Gabriel Barrios Barrios
Gabriel Pitollat Pitollat
Gabriel Barrios Barrios
Gabriel Barrios Barrios