Nutrition, memory and glucocorticoids
The objective of our team, in a perspective of healthy brain aging, is to better understand how unbalanced diets alter memory processes, and how specific micronutrients (vitamins, polyphenol) prevent memory decline. Two populations vulnerable to memory decline are targeted: obese children/adolescents and elderly. At the mechanistic level, the impact of nutritional status on glucocorticoid and endocannabinoid regulation is specifically studied knowing that they are critical for memory processes and metabolic response to nutrition. These scientific questions are tackled through animal models using behavioral , molecular and cellular analyses but also throgh clinical studies (FUI Nutrimémo, FUI Neurophénol, PHRC Corticodiab, ANR Obeteen, ANR ORUPS, LabEx Brain Clinique Obeteen, LabEx Brain HippoMeal).
Mots clés
Apprentissage, Déséquilibre alimentaire et vulnérabilité psychiatrique, Mémoire, Neuroimagerie chez l’humainSelected publications
- Spontaneous intake of essential oils after a negative postnatal experience has long-term effects on blood transcriptome in chickens.. Aline Foury, Anne Collin, Jean-Christophe Helbling, Christine Leterrier, Marie-Pierre Moisan, Laurence A. Guilloteau. Sci Rep. 2020-11-26. 10 (1)
- Bidirectional modulation of hippocampal and amygdala synaptic plasticity by post‐weaning obesogenic diet intake in male rats: Influence of the duration of diet exposure. Rose‐Marie Vouimba, Ioannis Bakoyiannis, Eva‐Gunnel Ducourneau, Mouna Maroun, Guillaume Ferreira. Hippocampus. 2020-11-04.
- Neuronal morphology and synaptic plasticity in the hippocampus of vitamin A deficient rats. Fabien Dumetz, Rachel Ginieis, Corinne Bure, Anaïs Marie, Serge Alfos, Véronique Pallet, Clémentine Bosch-Bouju. Nutritional Neuroscience. 2020-09-12. : 1-12.
- Food Disgust Scale: Spanish Version.. Leonor García-Gómez, César Romero-Rebollar, Christina Hartmann, Michael Siegrist, Guillaume Ferreira, Ruth Gutierrez-Aguilar, Salvador Villalpando, Gustavo Pacheco-Lopez. Front. Psychol.. 2020-02-07. 11
- Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation.. . Psychopharmacology (Berl). 2019 May;(5): doi: . Epub. 2019-05-23. 236 (5) : 1583-1596.
- Normalization of hippocampal retinoic acid level corrects age-related memory deficits in rats. Fabien Dumetz, Corinne Buré, Serge Alfos, Marc Bonneu, Emmanuel Richard, Katia Touyarot, Anaïs Marie, Jean-Marie Schmitter, Clémentine Bosch-Bouju, Véronique Pallet. Neurobiology of Aging. 2019-09-01.
- Housing Horses in Individual Boxes Is a Challenge with Regard to Welfare.. Alice Ruet, Julie Lemarchand, Céline Parias, Núria Mach, Marie-Pierre Moisan, Aline Foury, Christine Briant, Léa Lansade. Animals. 2019-08-28. 9 (9) : 621.
- Acute exposure to a high-fat diet in juvenile male rats disrupts hippocampal-dependent memory and plasticity through glucocorticoids.. Tala Khazen, Ossama A. Hatoum, Guillaume Ferreira, Mouna Maroun. Sci Rep. 2019-08-22. 9 (1)
- Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin-dependent kinase. Julie Brossaud ; Hélène Roumes ; Jean-Christophe Helbling ; Marie-Pierre Moisan ; Véronique Pallet ; Guillaume Ferreira ; Essi-Fanny Biyong ; Anabelle Redonnet; Jean-Benoît Corcuff. Molecular and Cellular Neuroscience. . 82 : 96-104.
- Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin-dependent kinase. Julie Brossaud ; Hélène Roumes ; Jean-Christophe Helbling ; Marie-Pierre Moisan ; Véronique Pallet ; Guillaume Ferreira ; Essi-Fanny Biyong ; Anabelle Redonnet; Jean-Benoît Corcuff. Molecular and Cellular Neuroscience. . 82 : 96-104.
- Decrease in Operant Responding Under Obesogenic Diet Exposure is not Related to Deficits in Incentive or Hedonic Processes.. Fabien Ducrocq, Alexia Hyde, Hortense Fanet, Asma Oummadi, Roman Walle, Véronique De Smedt-Peyrusse, Sophie Layé, Guillaume Ferreira, Pierre Trifilieff, Sylvie Vancassel. Obesity. 2018-12-30. 27 (2) : 255-263.
- Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity.. Célia Fourrier, Clémentine Bosch-Bouju, Raphaël Boursereau, Julie Sauvant, Agnès Aubert, Lucile Capuron, Guillaume Ferreira, Sophie Layé, Nathalie Castanon. Brain, Behavior, and Immunity. 2018-11-01.
- Hippocampal CB1 Receptors Control Incidental Associations.. Arnau Busquets-Garcia, José F. Oliveira da Cruz, Geoffrey Terral, Antonio C. Pagano Zottola, Edgar Soria-Gómez, Andrea Contini, Hugo Martin, Bastien Redon, Marjorie Varilh, Christina Ioannidou, Filippo Drago, Federico Massa, Xavier Fioramonti, Pierre Trifilieff, Guillaume Ferreira, Giovanni Marsicano. Neuron. 2018-09-01. 99 (6) : 1247-1259.e7.
- Insulin treatment partially prevents cognitive and hippocampal alterations as well as glucocorticoid dysregulation in early-onset insulin-deficient diabetic rats.. Nathalie Marissal-Arvy, Marie-Neige Campas, Audrey Semont, Céline Ducroix-Crepy, Marie-Christine Beauvieux, Julie Brossaud, Jean-Benoit Corcuff, Jean-Christophe Helbling, Sylvie Vancassel, Anne-Karine Bouzier-Sore, Katia Touyarot, Guillaume Ferreira, Pascal Barat, Marie-Pierre Moisan. Psychoneuroendocrinology. 2018-07-01. 93 : 72-81.
- Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin-dependent kinase 5.. Julie Brossaud, Hélène Roumes, Jean-Christophe Helbling, Marie-Pierre Moisan, Véronique Pallet, Guillaume Ferreira, Essi-Fanny Biyong, Anabelle Redonnet, Jean-Benoît Corcuff. Molecular and Cellular Neuroscience. 2017-07-01. 82 : 96-104.
Team member(s)
Chercheurs, Praticiens hospitaliers...
Catherine Noel-Suberville Noel-Suberville (University Teacher- Researcher)
Clémentine Bosch-Bouju Bosch-Bouju (University Teacher- Researcher)
Jean-Benoît Corcuff Corcuff (University teacher - researcher - Hospital practitioner)
Julie Brossaud Brossaud (University teacher - researcher - Hospital practitioner)
Katia Touyarot Touyarot (University Teacher- Researcher)
Nathalie Arvy Arvy (Researcher)
Pascal Barat Barat (University teacher - researcher - Hospital practitioner)
Paul Higueret Higueret (Professor Researcher emeritus)
Pauline Lafenêtre Lafenêtre (University Teacher- Researcher)
Véronique Pallet Pallet (University Teacher- Researcher)
Ingénieur(e)s, technicien(ne)s
Céline Ducroix-Crepy Ducroix-Crepy
Jean-Christophe Helbling Helbling
Serge Alfos Alfos
Post-doctorant(s)
Doctorant(s)