Neurogenesis and pathophysiology

Neurocentre Magendie

Voir la version en français

A growing body of evidences suggests that plasticity in the adult brain is involved in the pathophysiology of behavior. Recently, neurogenesis has been evidenced in the dentate gyrus (DG) of the hippocampal formation (HF), a brain structure involved in memory and emotion. This phenomenon has stimulated the interest for its potential involvement in the physiology and pathophysiology of hippocampal-dependant behavior. Our research has been dedicated to demonstrate that adult-born hippocampal neurons are a key player in memory and emotion and that a reduction of adult neurogenesis leads to the development of memory disorders, anxiety-like behavior and drug addiction. Our current project is designed to understand when and how adult neurogenesis impacts hippocampal-dependent behavior. In addition, the role of neurons born during DG development will be also scrutinized. In conclusion, this research proposal will provide a better understanding of the role of adult neurogenesis in normal and pathological behaviors. This knowledge will allow the development of new therapeutics tools for behavioral pathologies.

Selected publications

Team leader
Nora Abrous

Team member(s)

Chercheurs, Praticiens hospitaliers...

Emilie Pacary (Researcher)
Michel Le Moal (Emeritus Professor)
Muriel Koehl (Researcher)

Ingénieur(e)s, technicien(ne)s

Fanny Farrugia
Lisa Romero
Julie Mallet
Murielle Fèvre
Lili Cluzel-Burgalat
Estelle Cartier
Vanessa Charrier


Unis Bhat
Mathieu Mequinion


Neuropsychologist(s) and speech therapist(s)

Ingénieur(s) hospitalier(s) et ARC