Neurogenesis and pathophysiology
A growing body of evidences suggests that plasticity in the adult brain is involved in the pathophysiology of behavior. Recently, neurogenesis has been evidenced in the dentate gyrus (DG) of the hippocampal formation (HF), a brain structure involved in memory and emotion. This phenomenon has stimulated the interest for its potential involvement in the physiology and pathophysiology of hippocampal-dependant behavior. Our research has been dedicated to demonstrate that adult-born hippocampal neurons are a key player in memory and emotion and that a reduction of adult neurogenesis leads to the development of memory disorders, anxiety-like behavior and drug addiction. Our current project is designed to understand when and how adult neurogenesis impacts hippocampal-dependent behavior. In addition, the role of neurons born during DG development will be also scrutinized. In conclusion, this research proposal will provide a better understanding of the role of adult neurogenesis in normal and pathological behaviors. This knowledge will allow the development of new therapeutics tools for behavioral pathologies.
Mots clés
Attention, Cognition, Connectivité, Développement du système nerveux, Emotion, Environnement, Mémoire, Neuroadaptations, Optogénétique, Optogénétique et chemogénétique, Stress, Toxicomanie, Troubles addictifs, Troubles anxieux, Troubles du comportement, Vieillissement cognitifSelected publications
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Vangl2, a Core Component of the WNT/PCP Pathway, Regulates Adult Hippocampal Neurogenesis and Age-Related Decline in Cognitive Flexibility.
Muriel Koehl, Elodie Ladevèze, Mireille Montcouquiol, Djoher Nora Abrous.
Front Aging Neurosci.. 2022-03-04. 9 (14) : 844255.
DOI: 10.3389/fnagi.2022.844255 -
The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis.
Thomas Kerloch, Fanny Farrugia, Marlene Maitre, Geoffrey Terral, Muriel Koehl, Julian Ik-Tsen Heng, Mylene Blanchard, Helene Doat, Thierry Leste-Lasserre, Adeline Goron, Delphine Gonzales, Francois Guillemot, Nora Abrous, Emilie Pacary.
Mol Psy.. 2021-12. 26 : 7280–7295.
DOI: 10.1101/2020.09.10.290866 -
The temporal origin of dentate granule neurons dictates their role in spatial memory.
Nuria Masachs, Vanessa Charrier, Fanny Farrugia, Valerie Lemaire, Nicolas Blin, Wilfrid Mazier, Sophie Tronel, Marie-Françoise Montaron, Shaoyu Ge, Giovanni Marsicano, Daniela Cota, Véronique Deroche-Gamonet, Cyril Herry, Djoher Nora Abrous.
Mol Psychiatry. 2021-09-15.
DOI: 10.1038/s41380-021-01276-x -
A Baldwin interpretation of adult hippocampal neurogenesis: from functional relevance to physiopathology.
Djoher Nora Abrous, Muriel Koehl, Maël Lemoine.
Mol Psychiatry. 2021-06-08.
DOI: 10.1038/s41380-021-01172-4 -
Adult-born neurons immature during learning are necessary for remote memory reconsolidation in rats.
Marie Lods, Emilie Pacary, Wilfrid Mazier, Fanny Farrugia, Pierre Mortessagne, Nuria Masachs, Vanessa Charrier, Federico Massa, Daniela Cota, Guillaume Ferreira, Djoher Nora Abrous, Sophie Tronel.
Nat Commun. 2021-03-19. 12 (1)
DOI: 10.1038/s41467-021-22069-4 -
Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging.
Marie‐Françoise Montaron, Vanessa Charrier, Nicolas Blin, Pierre Garcia, Djoher Nora Abrous.
Aging Cell. 2020-06-29. 19 (8) : e13161.
DOI: 10.1111/acel.13161 -
Inhibition of mTOR signaling by genetic removal of p70 S6 Kinase 1 leads to anxiety-like disorders.
Muriel Koehl, Elodie Ladeveze, Caterina Catania, Daniela Cota, Djoher Nora Abrous.
. 2020-03-25.
DOI: 10.1101/2020.03.25.007427 -
Dentate Granule Neurons Generated During Perinatal Life Display Distinct Morphological Features Compared With Later-Born Neurons in the Mouse Hippocampus.
Thomas Kerloch, Solène Clavreul, Adeline Goron, Djoher Nora Abrous, Emilie Pacary.
Cerebral Cortex. 2018-09-12.
DOI: 10.1093/cercor/bhy224 -
Human Adult Neurogenesis: Evidence and Remaining Questions..
Gerd Kempermann, Fred H. Gage, Ludwig Aigner, Hongjun Song, Maurice A. Curtis, Sandrine Thuret, H. Georg Kuhn, Sebastian Jessberger, Paul W. Frankland, Heather A. Cameron, Elizabeth Gould, Rene Hen, D. Nora Abrous, Nicolas Toni, Alejandro F. Schinder, Xinyu Zhao, Paul J. Lucassen, Jonas Frisén.
Cell Stem Cell. 2018-07-01. 23 (1) : 25-30.
DOI: 10.1016/j.stem.2018.04.004 -
mTORC1 pathway disruption abrogates the effects of the ciliary neurotrophic factor on energy balance and hypothalamic neuroinflammation..
Caroline André, Caterina Catania, Julie Remus-Borel, Elodie Ladeveze, Thierry Leste-Lasserre, Wilfrid Mazier, Elke Binder, Delphine Gonzales, Samantha Clark, Omar Guzman-Quevedo, Djoher Nora Abrous, Sophie Layé, Daniela Cota.
Brain, Behavior, and Immunity. 2018-05-01. 70 : 325-334.
DOI: 10.1016/j.bbi.2018.03.014 -
Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior..
Véronique Deroche-Gamonet, Jean-Michel Revest, Jean-François Fiancette, Eric Balado, Muriel Koehl, Noëlle Grosjean, Djoher Nora Abrous, Pier-Vincenzo Piazza.
Mol Psychiatry. 2018-03-05. 24 (2) : 312-320.
DOI: 10.1038/s41380-018-0038-0
Team member(s)
Chercheurs, Praticiens hospitaliers...
Michel Le Moal Le Moal (Emeritus Professor)
Muriel Koehl Koehl (Researcher)
Ingénieur(e)s, technicien(ne)s
Lisa Romero Romero
Julie Mallet Mallet
Murielle Fèvre Fèvre
Lili Cluzel-Burgalat Cluzel-Burgalat
Estelle Cartier Cartier
Vanessa Charrier Charrier
Post-doctorant(s)
Doctorant(s)
Nicolas Blin Blin
Pierre Mortessagne Mortessagne
Loreen Rupprecht Rupprecht
Mohamed-Lyes Kaci Kaci
Carolina Nabais Nabais
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC