Monoamines, Parkinson and Pain

Our team is particularly interested in the role of monoaminergic systems in the pathophysiology of non-motor symptoms of Parkinson’s disease. We focus in particular on pain as a comorbidity of this neurodegenerative pathology but also as a pathology in its own. Indeed, chronic pain, whether or not associated with Parkinson’s disease, is a major public health problem and current treatments have little or no effect in relieving patients. Our objective is to better understand the plasticity that takes place in the dorsal horn of the spinal cord but also in the basal ganglia in order to allow the emergence of new effective therapies. We use integrated approaches to study neural networks, combining classical electrophysiology techniques with the most recent optogenetic, chemogenetic and calcium imaging approaches. Finally, we are also developing new approaches to electrophysiologically recording neuronal activity in freely moving animals and deep brain stimulation to improve the analysis, understanding and treatment of these pathologies.

Mots clés

Formation et fonctionnement des circuits neuronaux, Neurophysiologie, Optogénétique, Pain, Parkinson

Selected publications

1- . Covid-19 infection and Parkinsonism: is there a link? Bouali-Benazzouz R. and Benazzouz A. Mov Disord. 2021 doi: 10.1002/mds.28680.

2- Neuropathic pain modeling: Focus on synaptic and ion channel mechanisms. Bouali-Benazzouz R, Landry M, Benazzouz A, Fossat P. Prog Neurobiol. 2021 doi: 10.1016/j.pneurobio.2021.102030.

3- Cell-penetrating, antioxidant SELENOT mimetic protects dopaminergic neurons and ameliorates motor dysfunction in Parkinson’s disease animal models. Alsharifa I, Boukhzar L., Lefranca B., Godefroya D., Aury-Landasd J., do Regob J.L., do Regob J.C., Naudet F, Arabog F., Chagraouia A., Maltêtea D., Benazzouz A., Baugéd C., LeprinceaJ., Elkahlounh A.G., Eideni L.E. and Anouar Y. Redox Biol. 2021 Apr;40:101839. doi: 10.1016/j.redox.2020.101839.

4- Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor co-agonist D-serine. PNAS, June 8, 2021 https://doi.org/10.1073/pnas.2023750118. Glenn Dallerac , …, Pascal Fossat , Andrey Besedin , Jean-Michel Rivet , Joseph T. Coyle , Ginetta Collo , Loredano Pollegioni , Jan Kehr , Micaela Galante , Kevin Fone , Alain M Gardier , Thomas Freret , Angelo Contarino , Mark J Millan , Jean-Pierre Mothet.

5- Animal models of pain: Diversity and benefits. Abboud C, Duveau A, Bouali-Benazzouz R, Massé K, Mattar J, Brochoire L, Fossat P, Boué-Grabot E, Hleihel W, Landry M. J Neurosci Methods. 2021 Jan 15;348:108997. doi: 10.1016/j.jneumeth.2020.108997.

6- Lagière M., Bosc M., Whitestone S., Benazzouz A., Chagraoui A., Millan M.J. and De Deurwaerdère P. A Subset of Purposeless Oral Movements Triggered by Dopaminergic Agonists Is Modulated by 5-HT2C Receptors in Rats: Implication of the Subthalamic Nucleus. Int. J Mol Sci. 2020, 21(22), 8509. doi: 10.3390/ijms21228509.

7– Tibar H*., Naudet F.*, Kolbl F.*, … and Benazzouz A. In vivo validation of a new portable stimulator for chronic deep brain stimulation in freely moving rats. J Neurosci Methods. 2020, 333:108577. doi: 10.1016/j.jneumeth.2019.108577.

8– Windup of Nociceptive Flexion Reflex Depends on Synaptic and Intrinsic Properties of Dorsal Horn Neurons in Adult Rats. Aby F, Bouali-Benazzouz R, Landry M, Fossat P. Int J Mol Sci. 2019 Dec 5;20(24). pii: E6146. doi: 10.3390/ijms20246146.

9- Duality of 5-HT Effects on Crayfish Motoneurons. Bacqué-Cazenave J, Fossat P, Issa FA, Edwards DH, Delbecque JP, Cattaert D. Front Physiol. 2019 Oct 22;10:1280. doi: 10.3389/fphys.2019.01280. eCollection 2019.

10- Do arthropods feel anxious during molts? Bacqué-Cazenave J, Berthomieu M, Cattaert D, Fossat P*, Delbecque JP.* J Exp Biol. 2018 Dec 10. pii: jeb.186999. doi: 10.1242/jeb.186999. PMID:30530836

*Co-dernier auteur.

11- Acquisition of analgesic properties by the cholecystokinin (CCK)/CCK2 receptor system within the amygdala in a persistent inflammatory pain condition. Roca-Lapirot O, Fossat P, Ma S, Egron K, Trigilio G, López-González MJ, Covita J, Bouali-Benazzouz R, Favereaux A, Gundlach AL, Landry M. Pain. 2019 Feb;160(2):345-357. doi: 10.1097/j.pain.0000000000001408.

12– Tibar H., El Bayad K., Bouhouche A., Ait Ben Haddou E.H., Benomar A., Yahyaoui M., Benazzouz A.* and Regragui W.* Non-motor symptoms of Parkinson’s disease and their impact on quality of life in a cohort of Moroccan patients. Front. Neurol., 2018, April 04, 9:170. Doi: 10.3389/fneur.2018.00170. (*AB & WR contributed equally)

13- Neonatal 6-OHDA lesion model in mouse induces Attention-Deficit/ Hyperactivity Disorder (ADHD)-like behaviour. Bouchatta O, Manouze H, Bouali-Benazzouz R, Kerekes N, Ba-M’hamed S, Fossat P, Landry M, Bennis M. Sci Rep. 2018 Oct 18;8(1):15349. doi: 10.1038/s41598-018-33778-0. PMID:30337626

14- Alteration of nociceptive integration in the spinal cord of a rat model of Parkinson’s disease. Keri-Ann Charles, Frédéric Naudet, Rabia Bouali-Benazzouz, Marc Landry, Philippe De Deurwaerdère, Pascal Fossat,^# and Abdelhamid Benazzouz^#. Movement Disorder. 2018 Jul;33(6):1010-1015. doi: 10.1002/mds.2737. ^#Co dernier auteur.

15- Alteration of size perception: serotonin has opposite effects on the aggressiveness of crayfish confronting either a smaller or a larger rival. Bacqué-Cazenave J, Cattaert D, Delbecque JP, Fossat P. J Exp Biol. 2018 Jun 20;221(Pt 12). pii: jeb177840. doi: 10.1242/jeb.177840.

16- Inflammatory-induced spinal dorsal horn neurons hyperexcitability is mediated by P2X4 receptors. Aby F, Whitestone S, Landry M, Ulmann L, Fossat P. Pain Rep. 2018 May 23;3(3):e660. doi: 10.1097/PR9.0000000000000660. eCollection 2018 May.

17- Deep Brain Stimulation in Moroccan patients with Parkinson’s disease: The experience of Neurology Department of Rabat. Rahmani M., …, Benazzouz A. and Regragui W. Front. Neurol., 31 July 2018, Doi: 10.3389/fneur.2018.00532.

18- Serotonergic neurons mediate the anxiolytic effect of L-DOPA: neuronal correlates in the amygdala.Faggiani E., Naudet F., Janssen M.L.F., Temel Y. and Benazzouz A. Neurobiol. Dis. 2018, 110: 20–28, doi: 10.1016/j.nbd.2017.11.001.