Motoneurons and synaptic partners (MotoPSyn)
Our goal is to decipher the impact of the sensory-motor environment on both the global motor physiology and the possible development of motoneuronal pathologies. Using various animal models, including invertebrates, amphibians, rodents and humans that are complementary and offer specific opportunities, our research aims principally at understanding the fundamental processes of motoneuron development and motor functions physiology in a context of permanent interactions between single neurons, neuronal networks and sensory information. Specific projects focusing on various developmental and motor pathologies (ALS, ASS, vestibulopathies) are also conducted.
Mots clés
ASDs (Autism Spectrum Disorders), Assemblées neuronales, Connectivité, Développement du système nerveux, Formation et fonctionnement des circuits neuronaux, Motricité, Mouvement, Neurophysiologie, Plasticité des réseaux, Plasticité synaptique, Sclérose latérale amyotrophique, Sensory information processing, Troubles des comportements chez l’enfant et l’adolescentSelected publications
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Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity.
Juliette Boeri, Claude Meunier, Hervé Le Corronc, Pascal Branchereau, Yulia Timofeeva, François-Xavier Lejeune, Christine Mouffle, Hervé Arulkandarajah, Jean Marie Mangin, Pascal Legendre, Antonny Czarnecki.
eLife. 2021-04-26. 10
DOI: 10.7554/elife.62639 -
Bidirectional modulation of hippocampal and amygdala synaptic plasticity by post‐weaning obesogenic diet intake in male rats: Influence of the duration of diet exposure
Rose‐Marie Vouimba, Ioannis Bakoyiannis, Eva‐Gunnel Ducourneau, Mouna Maroun, Guillaume Ferreira.
Hippocampus. 2020-11-04.
DOI: 10.1002/hipo.23278 -
GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 Areas
Rose-Marie Vouimba, Rachel Anunu, Gal Richter-Levin.
Int J Mol Sci. 2020-05. 21 (11) : 3786.
DOI: 10.3390/ijms21113786 -
Implication of 5-HT in the Dysregulation of Chloride Homeostasis in Prenatal Spinal Motoneurons from the G93A Mouse Model of Amyotrophic Lateral Sclerosis
Elodie Martin, William Cazenave, Anne-Emilie Allain, Daniel Cattaert, Pascal Branchereau.
IJMS. 2020-02-07. 21 (3) : 1107.
DOI: 10.3390/ijms21031107 -
Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks
Pascal Branchereau, Elodie Martin, Anne-Emilie Allain, William Cazenave, Laura Supiot, Fara Hodeib, Amandine Laupénie, Urvashi Dalvi, Hongmei Zhu, Daniel Cattaert.
eLife. 2019-12-23. 8
DOI: 10.7554/elife.51402 -
Persistent sodium current drives excitability of immature Renshaw cells in early embryonic spinal networks.
Juliette Boeri, Hervé Le Corronc, François-Xavier Lejeune, Barbara Le Bras, Christine Mouffle, Monara Kaelle S.C. Angelim, Jean-Marie Mangin, Pascal Branchereau, Pascal Legendre and Antonny Czarnecki.
Journal of Neuroscience. 2018-08-29. 38 (35) : 7667-7682.
DOI: 10.1523/JNEUROSCI.3203-17.2018 -
Depolarizing GABA/glycine synaptic events switch from excitation to inhibition during frequency increases
Pascal Branchereau, Daniel Cattaert, Alain Delpy, Anne-Emilie Allain, Elodie Martin, Pierre Meyrand.
Sci Rep. 2016-02-25. 6 (1)
DOI: 10.1038/srep21753 -
Nonsynaptic glycine release is involved in the early KCC2 expression
Anne-Emilie Allain, William Cazenave, Alain Delpy, Prisca Exertier, Christophe Barthe, Pierre Meyrand, Daniel Cattaert, Pascal Branchereau.
Devel Neurobio. 2015-11-03. 76 (7) : 764-779.
DOI: 10.1002/dneu.22358 -
Juvenile obesity enhances emotional memory and amygdala plasticity through glucocorticoids.
C. Boitard, M. Maroun, F. Tantot, A. Cavaroc, J. Sauvant, A. Marchand, S. Laye, L. Capuron, M. Darnaudery, N. Castanon, E. Coutureau, R.-M. Vouimba, G. Ferreira.
Journal of Neuroscience. 2015-03-04. 35 (9) : 4092-4103.
DOI: 10.1523/jneurosci.3122-14.2015 -
VEGF modulates synaptic activity in the developing spinal cord
Sylvaine Guérit, Anne-Emilie Allain, Céline Léon, William Cazenave, Napoleone Ferrara, Pascal Branchereau, Andréas Bikfalvi.
Devel Neurobio. 2014-05-24. 74 (11) : 1110-1122.
DOI: 10.1002/dneu.22187 -
Acetylcholine controls GABA-, glutamate-, and glycine-dependent giant depolarizing potentials that govern spontaneous motoneuron activity at the onset of synaptogenesis in the mouse embryonic spinal cord
A. Czarnecki, H. Le Corronc, C. Rigato, B. Le Bras, F. Couraud, A.-L. Scain, A.-E. Allain, C. Mouffle, E. Bullier, J.-M. Mangin, P. Branchereau, P. Legendre.
Journal of Neuroscience. 2014-04-30. 34 (18) : 6389-6404.
DOI: 10.1523/JNEUROSCI.2664-13.2014 -
Embryonic alteration of motoneuronal morphology induces hyperexcitability in the mouse model of amyotrophic lateral sclerosis
Elodie Martin, William Cazenave, Daniel Cattaert, Pascal Branchereau.
Neurobiology of Disease. 2013-06-01. 54 : 116-126.
DOI: 10.1016/j.nbd.2013.02.011 -
Different patterns of amygdala priming differentially affect dentate gyrus plasticity and corticosterone, but not CA1 plasticity
Vouimba RM, Richter-Levin G..
Front Neural Circuits. 2013 May 3. 7 : 80.
DOI: 10.3389/fncir.2013.00080 -
Extracellular neural microstimulation may activate much larger regions than expected by simulations: a combined experimental and modeling study
Sébastien Joucla, Pascal Branchereau, Daniel Cattaert, Blaise Yvert.
PLoS ONE. 2012-08-07. 7 (8) : e41324.
DOI: 10.1371/journal.pone.0041324
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Guy Simonnet
Simonnet
(Former Hospital Practitionner - Emeritus)
Romuald Nargeot Nargeot (University Teacher- Researcher)
Denis Combes Combes (University Teacher- Researcher)
Antonny Czarnecki Czarnecki (Enseignant-chercheur)
Romuald Nargeot Nargeot (University Teacher- Researcher)
Denis Combes Combes (University Teacher- Researcher)
Antonny Czarnecki Czarnecki (Enseignant-chercheur)
Ingénieur(e)s, technicien(ne)s
William Cazenave
Cazenave
Post-doctorant(s)
Alexandra Reichova
Reichova
Doctorant(s)
Hongmei Zhu
Zhu
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC