Mechanisms of Adaptive Processes in brain circuits (MAP)
Mechanisms of Adaptive Processes in brain circuits (MAP)
The brain’s ability to constantly adapt its organization to ever-changing stimuli is termed “plasticity” and is a prominent feature of learning and memory in adults, as well as the assembly of neuronal circuits during critical developmental periods. Connections that convey relevant information and are the most active become stronger and stabilize, while less active ones weaken and eventually get eliminated, optimizing the storage and processing of information in the brain. Our research aims to examine the molecular and cellular mechanisms underlying these adaptive processes. We employ a multidisciplinary approach, including single-cell manipulation, electrophysiology, optogenetics, single-cell RNA sequencing, and high-resolution imaging, to better understand (1) how neuronal activity contributes to the molecular and functional diversification of glutamatergic synapses, (2) how synaptic plasticity shapes gene expression in neurons to support long-term synaptic changes, and (3) how astrocyte-neuron communication controls the development and plasticity of synaptic circuits.
Mots clés
ASDs (Autism Spectrum Disorders), Adhésion cellulaire et cytosquelette, Bio-informatique et analyse des données, Connectivité, Développement du système nerveux, Formation et fonctionnement des circuits neuronaux, Imagerie cellulaire in vitro ou in vivo, Interactions neurones-glie, Maladies Neuro-développementales, Microscopie super-résolutive, Neurophysiologie, Optogénétique, Optogénétique et chemogénétique, Physiologie synaptique, Plasticité synaptique, Synapse molecular complexes, Viral tracing, transcriptomiqueSelected publications
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Astrocyte Calcium Signaling Shifts the Polarity of Presynaptic Plasticity
Mathieu Letellier, Yukiko Goda.
Neuroscience. 2023-08-01. 525 : 38-46.
DOI: 10.1016/j.neuroscience.2023.05.032 -
miR ‐124‐dependent tagging of synapses by synaptopodin enables input‐specific homeostatic plasticity
Sandra Dubes, Anaïs Soula, Sébastien Benquet, Béatrice Tessier, Christel Poujol, Alexandre Favereaux, Olivier Thoumine, Mathieu Letellier.
The EMBO Journal. 2022-07-25.
DOI: 10.15252/embj.2021109012 -
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Andrea Toledo, Mathieu Letellier, Giorgia Bimbi, Béatrice Tessier, Sophie Daburon, Alexandre Favereaux, Ingrid Chamma, Kristel Vennekens, Jeroen Vanderlinden, Matthieu Sainlos, Joris de Wit, Daniel Choquet, Olivier Thoumine.
eLife. 2022-05-09. 11
DOI: 10.7554/elife.75233 -
Emerging Roles of Extracellular Vesicles in the Central Nervous System: Physiology, Pathology, and Therapeutic Perspectives.
Yadaly Gassama, Alexandre Favereaux.
Front. Cell. Neurosci.. 2021-02-23. 15
DOI: 10.3389/fncel.2021.626043 -
Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation
Mathieu Letellier, Matthieu Lagardère, Béatrice Tessier, Harald Janovjak, Olivier Thoumine.
eLife. 2020-04-23. 9
DOI: 10.7554/elife.52027 -
Differential role of pre- and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites
Mathieu Letellier, Florian Levet, Olivier Thoumine, Yukiko Goda.
PLoS Biol. 2019-06-05. 17 (6) : e2006223.
DOI: 10.1371/journal.pbio.2006223 -
Small RNA-Seq reveals novel miRNAs shaping the transcriptomic identity of rat brain structures
Anaïs Soula, Mélissa Valere, María-José López-González, Vicky Ury-Thiery, Alexis Groppi, Marc Landry, Macha Nikolski, Alexandre Favereaux.
Life Sci. Alliance. 2018-10-01. 1 (5) : e201800018.
DOI: 10.26508/lsa.201800018 -
A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation
Mathieu Letellier, Zsófia Szíber, Ingrid Chamma, Camille Saphy, Ioanna Papasideri, Béatrice Tessier, Matthieu Sainlos, Katalin Czöndör, Olivier Thoumine.
Nat Commun. 2018-09-28. 9 (1)
DOI: 10.1038/s41467-018-06220-2 -
Oxaliplatin treatment impairs extension of sensory neuron neurites in vitro through miR-204 overexpression.
María José López-González, Anaïs Soula, Marc Landry, Alexandre Favereaux.
NeuroToxicology. 2018-09-01. 68 : 91-100.
DOI: 10.1016/j.neuro.2018.07.009 -
Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone cancer pain.
Sara Elramah, María José López-González, Matthieu Bastide, Florence Dixmérias, Olivier Roca-Lapirot, Anne-Cécile Wielanek-Bachelet, Anne Vital, Thierry Leste-Lasserre, Alexandre Brochard, Marc Landry, Alexandre Favereaux.
Sci Rep. 2017-09-08. 7 (1)
DOI: 10.1038/s41598-017-10224-1 -
Astrocytes regulate heterogeneity of presynaptic strengths in hippocampal networks
Mathieu Letellier, Yun Kyung Park, Thomas E. Chater, Peter H. Chipman, Sunita Ghimire Gautam, Tomoko Oshima-Takago, Yukiko Goda.
Proc Natl Acad Sci USA. 2016-04-26. 113 (19) : E2685-E2694.
DOI: 10.1073/pnas.1523717113 -
miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling.
Mathieu Letellier, Sara Elramah, Magali Mondin, Anaïs Soula, Andrew Penn, Daniel Choquet, Marc Landry, Olivier Thoumine, Alexandre Favereaux.
Nat Neurosci. 2014-07-13. 17 (8) : 1040-1042.
DOI: 10.1038/nn.3762
Team member(s)
Chercheurs, Praticiens hospitaliers...
Ingénieur(e)s, technicien(ne)s
Chloé Desquines Desquines
Lucie Franco Franco
Méghane Sittewelle Sittewelle
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC