Endocannabinoids and neuroadaptation

Neurocentre Magendie

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Our team aims at uncovering the functions of the endocannabinoid system in the brain as well as the cannabinoids regulation of behavior and psychotic disorders. By using conditional mutagenesis, we are currently dissecting the roles of cannabinoid receptors type-1 (CB1) in different cellular and subcellular localizations towards a better understanding of the general rules governing behavior such as higher order memory processes, locomotor activity and sensory perception.

Innovative techniques : conditional mutagenesis, behaviour, analysis of mitochondrial functions in behaviour, in vivo & ex vivo electrophysiology, biochemistry, brain imaging.

Selected publications

Team leader

Team member(s)


Giovanni Marsicano (Team leader)


Chercheurs, Praticiens hospitaliers...

Federico Massa (Researcher)
Francis Chaouloff (Researcher)
Luigi Bellochio (Researcher)


Ingénieur(e)s, technicien(ne)s


Post-doctorant(s)

Jose Cruz
Ignacio Fernandez Moncada
Abel Eraso
Ana Covelo
Urszula Skupio


Doctorant(s)