Dynamics of neuronal and vascular networks underlying memory processing
Our team aims at elucidating the spatio-temporal evolution of memory traces and of their underlying cerebral support during memory processing in healthy and pathological conditions such as Alzheimer’s disease. We have made important breakthroughs, such as the identification of early tagging of cortical networks as a prerequisite for the formation of enduring associative memory. We also unraveled some of the molecular mechanisms involved in the formation of remote memories, including the interaction of the CaMKII protein with NMDA receptors known to play a key role in neuronal plasticity. Currently, our research focuses on the functional contribution of NMDA receptors subtypes and of their molecular partners, as well as that of vascular networks, to the stabilization of remote memories during the course of systems-level memory consolidation.
Mots clésAlzheimer, Apprentissage, Cognition, Démences, Mémoire, Plasticité synaptique, Unité neuro-vasculaire
- Early Tagging of Cortical Networks Is Required for the Formation of Enduring Associative Memory. Edith Lesburguères, Oliviero L. Gobbo, Stéphanie Alaux-Cantin, Anne Hambucken, Pierre Trifilieff, Bruno Bontempi. Science. 2011-02-18. 331 (619) : 924-928.
- A novel role for CAMKIIβ in the regulation of cortical neuron migration: implications for neurodevelopmental disorders.. Olivier Nicole, Donald M. Bell, Thierry Leste-Lasserre, Hélène Doat, François Guillemot, Emilie Pacary. Mol Psychiatry. 2018-04-30.
- Assessing recent and remote associative olfactory memory in rats using the social transmission of food preference paradigm. Benjamin Bessières, Olivier Nicole, Bruno Bontempi. Nat Protoc. 2017-06-22. 12 (7) : 1415-1436.
- Changes in C57BL6 mouse hippocampal transcriptome induced by hypergravity mimic acute corticosterone-induced stress. Alice Pulga, Yves Porte, Jean-Luc Morel. Front. Mol. Neurosci.. 2016-12-26. 9
- Soluble amyloid beta oligomers block the learning-induced increase in hippocampal sharp wave-ripple rate and impair spatial memory formation. Olivier Nicole, Senka Hadzibegovic, Judyta Gajda, Bruno Bontempi, Tiaza Bem, Pierre Meyrand. Sci Rep. 2016-03-07. 6 (1)
Bruno Bontempi Bontempi (Team leader)
Chercheurs, Praticiens hospitaliers...
CNRS UMR 5293 - Université de Bordeaux – Case 28
Centre Broca Nouvelle-Aquitaine - 3ème étage - 146 rue Léo Saignat - CS 61292 - 33076 Bordeaux cedex