Developmental Brain Physiology and Pathology


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A great challenge for our comprehension of the brain development is to identify how different biological signals converge and drive the maturation of excitatory synapses in the healthy and diseased brain. The goal of our lab is to use a multi-scale approach to decrypt the molecular mechanisms underpinning the maturation of the glutamatergic NMDA receptor-mediated signaling. How is this signaling regulated by scaffold proteins, transmembrane partners (e.g. dopamine receptors), molecules from the extracellular space, and the immune system? In addition, we investigate the instrumental role(s) of these molecular complexes in models of psychosis, in order to propose innovative therapeutical strategies.

Selected publications

Team leader
Laurent Groc

Team member(s)

Chercheurs, Praticiens hospitaliers...

Hélène Grea (University Teacher- Researcher)
Julien Dupuis (Researcher)
Olivier Nicole (Researcher)
Frédéric Villega (Researcher)

Ingénieur(e)s, technicien(ne)s

Delphine Bouchet-Tessier
Morgane Méras
Magalie Uriot
Romain Boularand
Thomas Lechanoine
Thomas Grard
Adèle Buckenmeyer


Ivo Calaresu
Dominique Fernandes


Neuropsychologist(s) and speech therapist(s)

Ingénieur(s) hospitalier(s) et ARC