Development of spinal motor networks in normal and pathologic conditions
The objective of our team is to better understand the mechanisms involved in the construction and maturation of mammal motor networks. We use wild-type (WT) mice and mice models of the disease amyotrophic lateral sclerosis (ALS). We focus our efforts on: 1) understanding, in WT mice, how early spinal motor networks generate a recurrent and powerful spontaneous activity that is necessary for developmental processes, 2) identifying early cellular and molecular mechanisms involved in the motor deficits observed in spinal motoneurons from two ALS mouse models and 3) decipher the implication of stress in the development of pathological motor networks and ALS symptoms.
Mots clés
Assemblées neuronales, Codage et intégration du signal, Comportement, Connectivité, Développement du système nerveux, Excitabilité neuronale, Formation et fonctionnement des circuits neuronaux, Modèle génétique, Modélisation des neurones et des réseaux de neurones, Motricité, Neurocomputation, Neurophysiologie, Optogénétique, Physiologie synaptique, Plasticité des réseaux, Plasticité synaptique, Sclérose latérale amyotrophique, Signalisation, Stress, Toxicomanie, Ultrastructure neuronale et morphogénèseSelected publications
- Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity.. Juliette Boeri, Claude Meunier, Hervé Le Corronc, Pascal Branchereau, Yulia Timofeeva, François-Xavier Lejeune, Christine Mouffle, Hervé Arulkandarajah, Jean Marie Mangin, Pascal Legendre, Antonny Czarnecki. eLife. 2021-04-26. 10
- Bidirectional modulation of hippocampal and amygdala synaptic plasticity by post‐weaning obesogenic diet intake in male rats: Influence of the duration of diet exposure. Rose‐Marie Vouimba, Ioannis Bakoyiannis, Eva‐Gunnel Ducourneau, Mouna Maroun, Guillaume Ferreira. Hippocampus. 2020-11-04.
- GABAergic Transmission in the Basolateral Amygdala Differentially Modulates Plasticity in the Dentate Gyrus and the CA1 Areas. Rose-Marie Vouimba, Rachel Anunu, Gal Richter-Levin. Int J Mol Sci. 2020-05. 21 (11) : 3786.
- Implication of 5-HT in the Dysregulation of Chloride Homeostasis in Prenatal Spinal Motoneurons from the G93A Mouse Model of Amyotrophic Lateral Sclerosis. Elodie Martin, William Cazenave, Anne-Emilie Allain, Daniel Cattaert, Pascal Branchereau. IJMS. 2020-02-07. 21 (3) : 1107.
- Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks. Pascal Branchereau, Elodie Martin, Anne-Emilie Allain, William Cazenave, Laura Supiot, Fara Hodeib, Amandine Laupénie, Urvashi Dalvi, Hongmei Zhu, Daniel Cattaert. eLife. 2019-12-23. 8
- Persistent sodium current drives excitability of immature Renshaw cells in early embryonic spinal networks.. Juliette Boeri, Hervé Le Corronc, François-Xavier Lejeune, Barbara Le Bras, Christine Mouffle, Monara Kaelle S.C. Angelim, Jean-Marie Mangin, Pascal Branchereau, Pascal Legendre and Antonny Czarnecki. Journal of Neuroscience. 2018-08-29. 38 (35) : 7667-7682.
- Depolarizing GABA/glycine synaptic events switch from excitation to inhibition during frequency increases. Pascal Branchereau, Daniel Cattaert, Alain Delpy, Anne-Emilie Allain, Elodie Martin, Pierre Meyrand. Sci Rep. 2016-02-25. 6 (1)
- Nonsynaptic glycine release is involved in the early KCC2 expression. Anne-Emilie Allain, William Cazenave, Alain Delpy, Prisca Exertier, Christophe Barthe, Pierre Meyrand, Daniel Cattaert, Pascal Branchereau. Devel Neurobio. 2015-11-03. 76 (7) : 764-779.
- Juvenile obesity enhances emotional memory and amygdala plasticity through glucocorticoids.. C. Boitard, M. Maroun, F. Tantot, A. Cavaroc, J. Sauvant, A. Marchand, S. Laye, L. Capuron, M. Darnaudery, N. Castanon, E. Coutureau, R.-M. Vouimba, G. Ferreira. Journal of Neuroscience. 2015-03-04. 35 (9) : 4092-4103.
- VEGF modulates synaptic activity in the developing spinal cord. Sylvaine Guérit, Anne-Emilie Allain, Céline Léon, William Cazenave, Napoleone Ferrara, Pascal Branchereau, Andréas Bikfalvi. Devel Neurobio. 2014-05-24. 74 (11) : 1110-1122.
- Acetylcholine controls GABA-, glutamate-, and glycine-dependent giant depolarizing potentials that govern spontaneous motoneuron activity at the onset of synaptogenesis in the mouse embryonic spinal cord. A. Czarnecki, H. Le Corronc, C. Rigato, B. Le Bras, F. Couraud, A.-L. Scain, A.-E. Allain, C. Mouffle, E. Bullier, J.-M. Mangin, P. Branchereau, P. Legendre. Journal of Neuroscience. 2014-04-30. 34 (18) : 6389-6404.
- Embryonic alteration of motoneuronal morphology induces hyperexcitability in the mouse model of amyotrophic lateral sclerosis. Elodie Martin, William Cazenave, Daniel Cattaert, Pascal Branchereau. Neurobiology of Disease. 2013-06-01. 54 : 116-126.
- Different patterns of amygdala priming differentially affect dentate gyrus plasticity and corticosterone, but not CA1 plasticity. Vouimba RM, Richter-Levin G.. Front Neural Circuits. 2013 May 3. 7 : 80.
- Extracellular neural microstimulation may activate much larger regions than expected by simulations: a combined experimental and modeling study. Sébastien Joucla, Pascal Branchereau, Daniel Cattaert, Blaise Yvert. PLoS ONE. 2012-08-07. 7 (8) : e41324.
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Rose-Marie Vouimba
Vouimba
(University Teacher- Researcher)
Antonny Czarnecki Czarnecki (Enseignant-chercheur)
Antonny Czarnecki Czarnecki (Enseignant-chercheur)
Ingénieur(e)s, technicien(ne)s
William Cazenave
Cazenave
Post-doctorant(s)
Doctorant(s)