Development of spinal motor networks in normal and pathologic conditions

The objective of our team is to better understand the mechanisms involved in the construction and maturation of mammal motor networks. We use wild-type (WT) mice and mice models of the disease amyotrophic lateral sclerosis (ALS). We focus our efforts on: 1) understanding, in WT mice, how early spinal motor networks generate a recurrent and powerful spontaneous activity that is necessary for developmental processes, 2) identifying early cellular and molecular mechanisms involved in the motor deficits observed in spinal motoneurons from two ALS mouse models and 3) decipher the implication of stress in the development of pathological motor networks and ALS symptoms.

Lab webpage