Development and Neurobiology of Neural Networks (DN3)
Our research aims to decipher the neurobiological bases of the development and functional plasticity of motor control neural networks at the cellular, network and integrated system levels during normal operation and pathological dysfunction (spinal cord injury, exposure to nanoparticles, central congenital hypoventilation syndrome). Our main focus is on locomotor, vestibular, gaze control and respiratory functions during early stages of development (embryonic, newborn and juvenile animals). For this, we use rodent (mouse, rat) and amphibian (xenopus) animal models that are amenable to in vitro and in vivo investigation, with the possible development of new specific transgenic lines, some of which will serve both fundamental and translational research purposes. We use multi-faceted approaches ranging from neural activity measurements (unitary and multi-cellular electrophysiology, nerve recordings, functional imaging, pharmacology treatments) and anatomical investigations (immunohistology, Clarity), to behavioral analyses (plethysmography, electromyography, kinematics, optogenetic) performed on our AniMotion plateform.
Until now, our research has made important contributions to unraveling neural processes involved in (1), the development of brainstem and spinal cord motor networks responsible for respiration, locomotion, posture and gaze-stabilizing eye movements, and (2) ,the functional coupling between different motor-to-motor, motor-to-sensory and sensory-to-motor circuits required for coordinating effective behavior. (3) We also developed several pathophysiological projects contributing to the fundamental description of neural network abnormal development with the added potential of supporting pre-clinical investigations. Our ongoing and future research aims continue now to investigate mechanisms underlying the development, modulation, coordination and plasticity of sensory-motor networks involved in the generation and regulation of automatic (breathing, locomotion) and non-automatic (gaze and posture stabilization) motor functions.
Mots clésAssemblées neuronales, Codage et intégration du signal, Connectivité, Développement du système nerveux, Excitabilité neuronale, Formation et fonctionnement des circuits neuronaux, Motricité, Mouvement, Neurophysiologie, Optogénétique, Physiologie synaptique, Plasticité des réseaux, Plasticité synaptique, Système auditif et d’équilibration
L-DOPA in Parkinson’s Disease: Looking at the “False” Neurotransmitters and Their Meaning.
Chagraoui A, Boulain M, Juvin L, Anouar Y, Barrière G, Deurwaerdère P.
Int J Mol Sci.. 2019 Dec 31. 21 (11)
Synergistic interaction between sensory inputs and propriospinal signaling underlying quadrupedal locomotion
Marie Boulain, Ines Khsime, Mélissa Sourioux, Muriel Thoby‐Brisson, Grégory Barrière, John Simmers, Didier Morin, Laurent Juvin.
J Physiol. 2021-08-19.
Acute exposure to zinc oxide nanoparticles critically disrupts operation of the respiratory neural network in neonatal rat.
Nicolosi A, Cardoit L, Pasquereau P, Jaillet C, Thoby-Brisson M, Juvin L, Morin D.
NeuroToxicology. 2018-07. 67 (150-160)
Stabilization of Gaze during Early Xenopus Development by Swimming-Related Utricular Signals.
François M. Lambert, Julien Bacqué-Cazenave, Anne Le Seach, Jessica Arama, Gilles Courtand, Michele Tagliabue, Selim Eskiizmirliler, Hans Straka, Mathieu Beraneck.
Current Biology. 2020-01-01.
Brainstem Steering of Locomotor Activity in the Newborn Rat
Zied Oueghlani, Cyril Simonnet, Laura Cardoit, Gilles Courtand, Jean-René Cazalets, Didier Morin, Laurent Juvin, Grégory Barrière.
J. Neurosci.. 2018-07-23. 38 (35) : 7725-7740.
Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus
Francois M Lambert, Laura Cardoit, Elric Courty, Marion Bougerol, Muriel Thoby-Brisson, John Simmers, Hervé Tostivint, Didier Le Ray.
eLife. 2018-05-30. 7
Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network
Marc Chevalier, Natalia Toporikova, John Simmers, Muriel Thoby-Brisson.
eLife. 2016-07-19. 5
Chercheurs, Praticiens hospitaliers...
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC