Development and adaptation of neuronal circuits


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A great challenge for our comprehension of the brain development is to identify how different biological signals converge and drive the maturation of excitatory synapses in the healthy and diseased brain. The goal of our lab is to use a multi-scale approach to decrypt the molecular mechanisms underpinning the maturation of the glutamatergic NMDA receptor-mediated signaling. How is this signaling regulated by scaffold proteins, transmembrane partners (e.g. dopamine receptors), molecules from the extracellular space, and the immune system? In addition, we investigate the instrumental role(s) of these molecular complexes in models of psychosis, in order to propose innovative therapeutical strategies.

Selected publications

Team leader
Laurent Groc

Team member(s)

Chercheurs, Praticiens hospitaliers...

Hélène Grea (University Teacher- Researcher)
Julien Dupuis (Researcher)
Olivier Nicole (Researcher)

Ingénieur(e)s, technicien(ne)s

Audrey Barranger
Delphine Bouchet-Tessier
Elise Goyet
Théo Baurberg
Laurine Bastardo
Morgane Méras


Diego Grassi
Mar Petit-Pedrol
Ivo Calaresu


Neuropsychologist(s) and speech therapist(s)

Ingénieur(s) hospitalier(s) et ARC