Computational and systems neuroscience


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Neocortical function and plasticity underlie the remarkable adaptive skills of mammals. Among different projects, our team is studying how the prefrontal cortex computes and adapts its strategies through experience and learning to optimally select the sequence of actions that is expected to produce the most beneficial outcome. We developed an entirely in vivo multidisciplinary approach combining electrophysiology and functional imaging (intrinsic and voltage-sensitive dyes imaging), multiphoton laser-scanning microscopy, gene transfer and optogenetic during behavior in head-fixed and freely-moving mice.
Innovative techniques: in vivo patch-clamp and optogenetic, chronic two-photon imaging during behavior. decision-making in virtual reality. high-dimentional analysis of brain circuit.

Selected publications

Team leader

Team member(s)

Frédéric Gambino (Team leader)

Chercheurs, Praticiens hospitaliers...

Ingénieur(e)s, technicien(ne)s


Nicolas Chenouard
Vladimir Kouskoff
Aron De Miranda