Watching neuronal circuit dynamics through functional multineuron calcium imaging (fMCI)

Naoya Takahashi, Takuya Sasaki, Atsushi Usami, Norio Matsuki, Yuji Ikegaya
Neuroscience Research. 2007-07-01; 58(3): 219-225
DOI: 10.1016/j.neures.2007.03.001

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Functional multineuron calcium imaging (fMCI) is a large-scale optical recording
technique that monitors the spatiotemporal pattern of action potentials, all at
once, from large neuron populations. fMCI has unique advantages, including: (i)
simultaneous recording from >1000 neurons in a wide area, (ii) single-cell
resolution, (iii) identifiable location of neurons and (iv) detection of
non-active neurons during the observation period. We review herein the principle,
history, utility and limitations of fMCI.

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