Voltage-gated sodium channel organization in neurons: protein interactions and trafficking pathways.
Neuroscience Letters. 2010-12-01; 486(2): 92-100
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1. Neurosci Lett. 2010 Dec 10;486(2):92-100. doi: 10.1016/j.neulet.2010.08.079. Epub
2010 Sep 21.
Voltage-gated sodium channel organization in neurons: protein interactions and
Leterrier C(1), Brachet A, Fache MP, Dargent B.
(1)INSERM UMR 641, Marseille F-13916, France.
In neurons, voltage-gated sodium (Nav) channels underlie the generation and
propagation of the action potential. The proper targeting and concentration of
Nav channels at the axon initial segment (AIS) and at the nodes of Ranvier are
therefore vital for neuronal function. In AIS and nodes, Nav channels are part of
specific supra-molecular complexes that include accessory proteins, adhesion
proteins and cytoskeletal adaptors. Multiple approaches, from biochemical
characterization of protein-protein interactions to functional studies using
mutant mice, have addressed the mechanisms of Nav channel targeting to AIS and
nodes. This review summarizes our current knowledge of both the intrinsic
determinants and the role of partner proteins in Nav targeting. A few fundamental
trafficking mechanisms, such as selective endocytosis and diffusion/retention,
have been characterized. However, a lot of exciting questions are still open,
such as the mechanism of differentiated Nav subtype localization and targeting,
and the possible interplay between electrogenesis properties and Nav
concentration at the AIS and the nodes.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
PMID: 20817077 [Indexed for MEDLINE]