Ultra-short screening instruments for major depressive episode and generalized anxiety disorder in epilepsy: The NDDIE-2 and the GAD-SI

Jean-Arthur Micoulaud-Franchi, Fabrice Bartolomei, Aileen McGonigal
Journal of Affective Disorders. 2017-03-01; 210: 237-240
DOI: 10.1016/j.jad.2016.12.038

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1. J Affect Disord. 2017 Mar 1;210:237-240. doi: 10.1016/j.jad.2016.12.038. Epub
2016 Dec 27.

Ultra-short screening instruments for major depressive episode and generalized
anxiety disorder in epilepsy: The NDDIE-2 and the GAD-SI.

Micoulaud-Franchi JA(1), Bartolomei F(2), McGonigal A(3).

Author information:
(1)Services d’explorations fonctionnelles du système nerveux, Clinique du
sommeil, CHU de Bordeaux, Place Amélie Raba-Leon, 33076 Bordeaux, France; USR
CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, France.
(2)Service de Neurophysiologie Clinique, APHM, Hôpital de la Timone, 13005
Marseille, France; INSERM UMR 1106, INS, 27 Bd Jean Moulin, 13385 Marseille,
France; Aix Marseille Université, Faculté de Médecine, Marseille, France; Hôpital
Henri Gastaut, Etablissement Hospitalier Spécialisé dans le traitement des
Epilepsies, 300 Boulevard de Sainte-Marguerite, 13009 Marseille, France.
(3)Service de Neurophysiologie Clinique, APHM, Hôpital de la Timone, 13005
Marseille, France; INSERM UMR 1106, INS, 27 Bd Jean Moulin, 13385 Marseille,
France; Aix Marseille Université, Faculté de Médecine, Marseille, France.
Electronic address: .

BACKGROUND: Systematic screening is recommended for major depressive episode
(MDE) with the Neurological Disorders Depression Inventory for Epilepsy NDDI-E, 6
items and generalized anxiety disorder (GAD) with the GAD 7 items in patients
with epilepsy (PWE). Shorter versions of the NDDI-E and the GAD-7 could
facilitate increased screening by busy clinicians and be more accessible to
patients with mild cognitive and/or language impairments.
METHODS: The effectiveness of ultra-short versions of the NDDI-E (2 items) and
the GAD-7 (the GAD-2, 2 items, and the GAD-SI with a single item) in comparison
with the original versions were statistically tested using ROC analysis.
RESULTS: ROC analysis of the NDDIE-2 showed an AUC of 0.926 (p

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