Towards a unified analysis of brain maturation and aging across the entire lifespan: A MRI analysis.

Pierrick Coupé, Gwenaelle Catheline, Enrique Lanuza, José Vicente Manjón,
Hum. Brain Mapp.. 2017-07-24; 38(11): 5501-5518
DOI: 10.1002/hbm.23743

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1. Hum Brain Mapp. 2017 Nov;38(11):5501-5518. doi: 10.1002/hbm.23743. Epub 2017 Jul

Towards a unified analysis of brain maturation and aging across the entire
lifespan: A MRI analysis.

Coupé P(1)(2), Catheline G(3), Lanuza E(4), Manjón JV(5); Alzheimer’s Disease
Neuroimaging Initiative.

Author information:
(1)University of Bordeaux, LaBRI, UMR 5800, PICTURA, Talence, F-33400, France.
(2)CNRS, LaBRI, UMR 5800, PICTURA, Talence, F-33400, France.
(3)University of Bordeaux, CNRS, EPHE PSL Research University of, INCIA, UMR
5283, Bordeaux, F-33000, France.
(4)Department of Cell Biology, University of Valencia, Burjassot, Valencia,
46100, Spain.
(5)Instituto Universitario de Tecnologías de la Información y Comunicaciones
(ITACA), Universitat Politècnica de València, Camino de Vera s/n, Valencia,
46022, Spain.

There is no consensus in literature about lifespan brain maturation and
senescence, mainly because previous lifespan studies have been performed on
restricted age periods and/or with a limited number of scans, making results
instable and their comparison very difficult. Moreover, the use of nonharmonized
tools and different volumetric measurements lead to a great discrepancy in
reported results. Thanks to the new paradigm of BigData sharing in neuroimaging
and the last advances in image processing enabling to process baby as well as
elderly scans with the same tool, new insights on brain maturation and aging can
be obtained. This study presents brain volume trajectory over the entire lifespan
using the largest age range to date (from few months of life to elderly) and one
of the largest number of subjects (N = 2,944). First, we found that white matter
trajectory based on absolute and normalized volumes follows an inverted U-shape
with a maturation peak around middle life. Second, we found that from 1 to 8-10 y
there is an absolute gray matter (GM) increase related to body growth followed by
a GM decrease. However, when normalized volumes were considered, GM continuously
decreases all along the life. Finally, we found that this observation holds for
almost all the considered subcortical structures except for amygdala which is
rather stable and hippocampus which exhibits an inverted U-shape with a longer
maturation period. By revealing the entire brain trajectory picture, a consensus
can be drawn since most of the previously discussed discrepancies can be
explained. Hum Brain Mapp 38:5501-5518, 2017. © 2017 Wiley Periodicals, Inc.

© 2017 Wiley Periodicals, Inc.

DOI: 10.1002/hbm.23743
PMCID: PMC6866824
PMID: 28737295 [Indexed for MEDLINE]

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