Toward a unified analysis of cerebellum maturation and aging across the entire lifespan: A MRI analysis.

José E. Romero, Pierrick Coupe, Enrique Lanuza, Gwenaelle Catheline, José V. Manjón,
Hum Brain Mapp. 2021-01-01; 42(5): 1287-1303
DOI: 10.1002/hbm.25293

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Romero JE(1), Coupe P(2)(3), Lanuza E(4), Catheline G(3), Manjón JV(1); Alzheimer’s Disease Neuroimaging Initiative.

Author information:
(1)Instituto de Aplicaciones de las Tecnologías de la Información y de las
Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, Valencia,
(2)CNRS, University of Bordeaux, Bordeaux INP, LABRI, UMR5800, Talence, France.
(3)CNRS, EPHE PSL Research University of, INCIA, UMR 5283, University of
Bordeaux, Bordeaux, France.
(4)Department of Cell Biology, University of Valencia, Valencia, Spain.

Previous literature about the structural characterization of the human cerebellum
is related to the context of a specific pathology or focused in a restricted age
range. In fact, studies about the cerebellum maturation across the lifespan are
scarce and most of them considered the cerebellum as a whole without
investigating each lobule. This lack of study can be explained by the lack of
both accurate segmentation methods and data availability. Fortunately, during the
last years, several cerebellum segmentation methods have been developed and many
databases comprising subjects of different ages have been made publically
available. This fact opens an opportunity window to obtain a more extensive
analysis of the cerebellum maturation and aging. In this study, we have used a
recent state-of-the-art cerebellum segmentation method called CERES and a large
data set (N = 2,831 images) from healthy controls covering the entire lifespan to
provide a model for 12 cerebellum structures (i.e., lobules I-II, III, IV, VI,
Crus I, Crus II, VIIB, VIIIA, VIIIB, IX, and X). We found that lobules have
generally an evolution that follows a trajectory composed by a fast growth and a
slow degeneration having sometimes a plateau for absolute volumes, and a
decreasing tendency (faster in early ages) for normalized volumes. Special
consideration is dedicated to Crus II, where slow degeneration appears to
stabilize in elder ages for absolute volumes, and to lobule X, which does not
present any fast growth during childhood in absolute volumes and shows a slow
growth for normalized volumes.

© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.


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