Time course of brain volume changes in the preclinical phase of Alzheimer’s disease.
Alzheimer's & Dementia. 2014-01-13; 10(2): 143-151.e1
DOI: 10.1016/j.jalz.2013.08.279
Read on PubMed
1. Alzheimers Dement. 2014 Mar;10(2):143-151.e1. doi: 10.1016/j.jalz.2013.08.279.
Epub 2014 Jan 10.
Time course of brain volume changes in the preclinical phase of Alzheimer’s
disease.
Bernard C(1), Helmer C(2), Dilharreguy B(3), Amieva H(4), Auriacombe S(5),
Dartigues JF(5), Allard M(6), Catheline G(6).
Author information:
(1)University of Bordeaux, INCIA, Talence, France; CNRS, INCIA, Talence, France;
EPHE, Bordeaux, France. Electronic address: .
(2)INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux,
France; University of Bordeaux, Bordeaux, France; INSERM, Clinical Investigation
Center-Clinical Epidemiology 7, Bordeaux, France.
(3)University of Bordeaux, INCIA, Talence, France; CNRS, INCIA, Talence, France.
(4)INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux,
France; University of Bordeaux, Bordeaux, France.
(5)INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux,
France; University of Bordeaux, Bordeaux, France; University Hospital, Memory
Consultation, CMRR, Bordeaux, France.
(6)University of Bordeaux, INCIA, Talence, France; CNRS, INCIA, Talence, France;
EPHE, Bordeaux, France.
BACKGROUND: Structural alterations of a large network characterize Alzheimer’s
disease (AD), but the time course of these changes remains unclear. The dynamic
of these alterations was examined in the AD preclinical phase using data from the
10-year follow-up of a population-based cohort (Bordeaux-3City).
METHODS: Participants received neuropsychological assessments every 2 years and
two identical magnetic resonance imaging (MRI) exams at baseline and 4 years
later. Twenty-five incident AD cases were compared with 319 subjects who remained
free of dementia. Subjects were free of dementia at baseline and at follow-up
MRI. Incident AD occurred after these time points.
RESULTS: At baseline, incident AD already presented smaller volumes only in the
left amygdalo-hippocampal complex. Moreover, a higher annual rate of atrophy of
the temporoparietal cortices was observed in future AD subjects during the
following 4 years.
CONCLUSION: Incident AD cases present mediotemporal lesions up to 5 years before
diagnosis. This neurodegenerative process seems to progressively reach the
temporoparietal cortices in the AD preclinical phase.
Copyright © 2014 The Alzheimer’s Association. Published by Elsevier Inc. All
rights reserved.
DOI: 10.1016/j.jalz.2013.08.279
PMID: 24418054 [Indexed for MEDLINE]