Thermally induced birefringence changes in cartilage using polarization sensitive optical coherence tomography
Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical. 2001-07-09; :
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1. J Gastroenterol Hepatol. 2008 May;23(5):783-9. Epub 2007 Jul 21.
Association of cytokine gene polymorphisms and liver fibrosis in chronic
Chan HL(1), Tse AM, Chim AM, Wong VW, Choi PC, Yu J, Zhang M, Sung JJ.
(1)Institute of Digestive Disease and Department of Medicine and Therapeutics,
The Chinese University of Hong Kong, Hong Kong.
BACKGROUND AND AIM: As liver fibrosis is the result of persistent
necroinflammation in the liver, pro-inflammatory cytokines secreted in response
to cell injury have a central role in the pathogenesis of liver fibrosis. We
aimed to investigate the association of cytokine gene polymorphism and liver
fibrosis among Chinese patients with chronic hepatitis B.
METHODS: Polymorphisms at interleukin-10 (IL-10-627, -1117), interleukin-1-beta
(IL-1beta-511, -31, -3964), interleukin-1 receptor antagonist (IL-1RN), and tumor
necrosis factor-alpha (TNF-alpha-308, -238) among Chinese chronic hepatitis B
patients were determined. Severe liver fibrosis was defined as Ishak fibrosis
score = 4 (of 6).
RESULTS: Fifty-nine of 273 (22%) patients had severe fibrosis. The distribution
of genotypes for IL-10-627 was CC (11%), CA (41%), and AA (48%). The CC genotype
at IL-10-627 was protective against severe fibrosis (odds ratio (OR) 0.11; 95% CI
0.014-0.82; P = 0.032). After adjusted for baseline variables, the adjusted OR of
CC genotypes at IL-10-627 for severe fibrosis was 0.063 (95% CI 0.06-0.64; P =
0.063). Other gene polymorphisms at IL-1beta, IL-1RN, TNF-alpha, and IL-10 had no
significant association with severe fibrosis. Weak linkage disequilibrium was
observed between IL-10-627 and IL-10-1117 with linkage disequilibrium coefficient
of 0.12 (P < 0.001). The distribution of haplotypes of IL-10-1117 and IL-10-627
was A-A (69%), A-C (26%), and G-C (5%). High and intermediate IL-10 production
(A-C and G-C) haplotypes were protective against severe fibrosis (OR 0.62; 95% CI
0.39-0.99; P = 0.046).
CONCLUSIONS: High production genotype and haplotypes of IL-10 were associated
with less severe liver fibrosis in chronic hepatitis B in Chinese.
PMID: 17645476 [Indexed for MEDLINE]