The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011-08-01; :
DOI: 10.1109/IEMBS.2011.6090148
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1. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:663-6. doi:
10.1109/IEMBS.2011.6090148.
The translational value of the MPTP non-human primate model of Parkinsonism for
deep brain stimulation research.
Tass PA(1), Qin L, Hauptmann C, Dovero S, Bezard E, Boraud T, Meissner WG.
Author information:
(1)Institute of Neuroscience and Medicine-Neuromodulation, Research Centre
Juelich, Germany.
Deep brain stimulation (DBS) has been applied in more than 70000 patients
worldwide during the last two decades. The main target is the subthalamic nucleus
(STN) for the treatment of motor complications in late stage Parkinson’s disease
(PD). Positive results in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-treated non-human primates have set the grounds for its successful
translation to PD patients. Since then, this model has allowed gaining
significant insights in the underlying mechanisms of action of DBS and is
currently being used for the development of new stimulation techniques.
Altogether, this underpins the high potential of this preclinical model for
future translation of DBS research in PD.
DOI: 10.1109/IEMBS.2011.6090148
PMID: 22254396 [Indexed for MEDLINE]