The pre-Bötzinger oscillator in the mouse embryo

C. Borday, C. Vias, S. Autran, M. Thoby-Brisson, J. Champagnat, G. Fortin
Journal of Physiology-Paris. 2006-11-01; 100(5-6): 284-289
DOI: 10.1016/j.jphysparis.2007.05.007

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1. J Physiol Paris. 2006 Nov-Dec;100(5-6):284-9. Epub 2007 Jun 8.

The pre-Bötzinger oscillator in the mouse embryo.

Borday C(1), Vias C, Autran S, Thoby-Brisson M, Champagnat J, Fortin G.

Author information:
(1)Neurobiologie Génétique et Intégrative, Institut de Neurobiologie Alfred
Fessard, CNRS, 1 av. de la terrasse, 91198 Gif sur Yvette, France.

Studies of the sites and mechanisms involved in mammalian respiratory rhythm
generation point to two clusters of rhythmic neurons forming a coupled oscillator
network within the brainstem. The location of these oscillators, the
pre-Bötzinger complex (preBötC) at vagal level, and the para-facial respiratory
group at facial level, probably result from regional patterning schemes
specifying neural types in the hindbrain during embryogenesis. Here, we report
evidence that the preBötC oscillator (i) is first active at embryonic stages,
(ii) originates in the post-otic hindbrain neural tube and (iii) requires the
glutamate vesicular transporter 2 for rhythm generation.

DOI: 10.1016/j.jphysparis.2007.05.007
PMID: 17628453 [Indexed for MEDLINE]

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