The effect of CNS activation versus EEG arousal during sleep on heart rate response and daytime tests
Clinical Neurophysiology. 2006-04-01; 117(4): 731-739
DOI: 10.1016/j.clinph.2005.08.035
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1. Clin Neurophysiol. 2006 Apr;117(4):731-9. Epub 2006 Feb 2.
The effect of CNS activation versus EEG arousal during sleep on heart rate
response and daytime tests.
Guilleminault C(1), Abad VC, Philip P, Stoohs R.
Author information:
(1)Stanford Sleep Disorders Center, Stanford University, 401 Quarry Road Suite
3301, Stanford, CA 94305-5730, USA.
Comment in
Clin Neurophysiol. 2006 Apr;117(4):707-11.
OBJECTIVE: To induce a heart rate change in normal subjects using auditory
stimulation without inducing EEG arousals and to assess the effects on daytime
functioning and compare results to auditory stimulation leading to short EEG
arousals.
METHODS: Six normal young men initially randomized into two groups (A and B)
underwent 4 nights of nocturnal polysomnography (normal sleep on night 1,
auditory stimulation without EEG arousal or normal sleep on nights 2 and 3 using
Latin square design, and auditory stimulation with EEG arousal on night 4). MSLT
and PVT were performed during days following nights 2-4.
RESULTS: MSLT and PVT results showed significant differences after EEG arousal
compared to stimulation without EEG arousal and to normal sleep; there were no
significant differences after normal sleep compared to stimulation without EEG
arousal. RR interval showed significant differences during undisturbed sleep
compared to stimulation without EEG arousal and to stimulation with EEG arousal;
RR interval without EEG arousal also differed significantly from RR interval with
EEG arousal.
CONCLUSION: Activation of the brain-stem can lead to autonomic nervous system
(ANS) response without objective consequences the next day.
SIGNIFICANCE: ANS responses induced by auditory stimulation during sleep without
EEG arousal do not have the same effects on daytime sleepiness and performance as
sleep fragmentation associated with EEG arousals.
DOI: 10.1016/j.clinph.2005.08.035
PMID: 16458068 [Indexed for MEDLINE]