The distribution and physiological effects of three evolutionarily and sequence-related neuropeptides in rhodnius prolixus: Adipokinetic hormone, corazonin and adipokinetic hormone/corazonin-related peptide

H. Patel, I. Orchard, J.A. Veenstra, A.B. Lange
General and Comparative Endocrinology. 2014-01-01; 195: 1-8
DOI: 10.1016/j.ygcen.2013.10.012

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Patel H(1), Orchard I(2), Veenstra JA(3), Lange AB(4).

Author information:
(1)Department of Biology, University of Toronto Mississauga, 3359 Mississauga
Rd., Mississauga, ON L5L 1C6, Canada. Electronic address:
.
(2)Department of Biology, University of Toronto Mississauga, 3359 Mississauga
Rd., Mississauga, ON L5L 1C6, Canada. Electronic address:
.
(3)Université de Bordeaux, INCIA UMR 5287 CNRS, 33400 Talence, France. Electronic
address: .
(4)Department of Biology, University of Toronto Mississauga, 3359 Mississauga
Rd., Mississauga, ON L5L 1C6, Canada. Electronic address:
.

Republished in
Gen Comp Endocrinol. 2014 Jul 1;203:307-14.

We have examined the distribution and physiological effects of three
evolutionarily and sequence-related neuropeptides in Rhodnius prolixus. These
neuropeptides, adipokinetic hormone (RhoprAKH), corazonin (CRZ) and adipokinetic
hormone/corazonin-related peptide (RhoprACP) are present in distinct,
non-overlapping neuronal subsets in the central nervous system (CNS), as
determined by immunohistochemistry. Corazonin-like immunoreactive cell bodies are
present in the brain and ventral nerve cord, whereas ACP-like immunoreactive cell
bodies are only present in the brain, and AKH-like immunoreactive cell bodies
only present in the corpus cardiacum (CC). The immunoreactivity to ACP, CRZ and
AKH in R. prolixus suggests that ACP and CRZ are released within the CNS, and
that CRZ and AKH are released as neurohormones from the CC. Injection of RhoprAKH
into adult males elevated haemolymph lipid levels, but injection of CRZ or
RhoprACP failed to have any effect on haemolymph lipid levels. Corazonin
stimulated an increase in heart-beat frequency in vitro, but RhoprAKH and
RhoprACP failed to do so. Thus, although all three neuropeptides share sequence
similarity, the AKH and CRZ receptors only respond to their own ligand.

Copyright © 2013 Elsevier Inc. All rights reserved.

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