The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain
Nat Commun. 2019-03-29; 10(1):
DOI: 10.1038/s41467-019-09344-1
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Karolis VR(1)(2), Corbetta M(3)(4)(5)(6)(7)(8), Thiebaut de Schotten M(9)(10)(11).
Author information:
(1)Brain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris, France. .
(2)Frontlab, Institut du Cerveau et de la Moelle épinière (ICM), Sorbonne
Universities, Inserm U 1127, CNRS UMR 7225, Paris, France.
.
(3)Department of Neuroscience, University of Padova, Padova, Italy.
(4)Padova Neuroscience Center (PNC), University of Padova, Padova, Italy.
(5)Venetian Institute of Molecular Medicine, Fondazione Biomedica, Padova, Italy.
(6)Department of Neurology, Washington University, Saint Louis, MO, USA.
(7)Department of Radiology, Washington University, Saint Louis, MO, USA.
(8)Department of Neuroscience, Washington University, Saint Louis, MO, USA.
(9)Brain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris,
France. .
(10)Frontlab, Institut du Cerveau et de la Moelle épinière (ICM), Sorbonne Universities, Inserm U 1127, CNRS UMR 7225, Paris, France.
.
(11)Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, Bordeaux, France. .
Functional lateralisation is a fundamental principle of the human brain. However,
a comprehensive taxonomy of functional lateralisation and its organisation in the
brain is missing. Here, we report the first complete map of functional
hemispheric asymmetries in the human brain, reveal its low dimensional structure,
and its relationship with structural inter-hemispheric connectivity. Our results
suggest that the lateralisation of brain functions is distributed along four
functional axes: symbolic communication, perception/action, emotion, and
decision-making. The similarity between this finding and recent work on
neurological symptoms give rise to new hypotheses on the mechanisms that support
brain recovery after a brain lesion. We also report that cortical regions showing
asymmetries in task-evoked activity have reduced connections with the opposite
hemisphere. This latter result suggests that during evolution, brain size
expansion led to functional lateralisation to avoid excessive conduction delays
between the hemispheres.
DOI: 10.1038/s41467-019-09344-1
PMCID: PMC6441088
PMID: 30926845 [Indexed for MEDLINE]