Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of Hippocampal CA1 N-Methyl-D-Aspartate Receptors.
Biological Psychiatry. 2016-05-01; 79(9): 735-745
DOI: 10.1016/j.biopsych.2015.07.017
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1. Biol Psychiatry. 2016 May 1;79(9):735-45. doi: 10.1016/j.biopsych.2015.07.017.
Epub 2015 Jul 31.
Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of
Hippocampal CA1 N-Methyl-D-Aspartate Receptors.
Potier M(1), Georges F(2), Brayda-Bruno L(1), Ladépêche L(2), Lamothe V(1), Al
Abed AS(1), Groc L(2), Marighetto A(3).
Author information:
(1)Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862
l’Institut National de la Santé et de la Recherche Médicale, Bordeaux, France;
Université de Bordeaux (MP, FG, LB-B, LL, VL, SAA, LG), Bordeaux, France.
(2)Interdisciplinary Institute for NeuroSciences (FG, LL, LG, AM), Centre
National de la Recherche Scientifique, Unite Mixte de Recherche 5297, Bordeaux,
France; Université de Bordeaux (MP, FG, LB-B, LL, VL, SAA, LG), Bordeaux, France.
(3)Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862
l’Institut National de la Santé et de la Recherche Médicale, Bordeaux, France;
Interdisciplinary Institute for NeuroSciences (FG, LL, LG, AM), Centre National
de la Recherche Scientifique, Unite Mixte de Recherche 5297, Bordeaux, France.
Electronic address: .
BACKGROUND: Identifying the underlying cellular mechanisms of episodic memory is
an important challenge, since this memory, based on temporal and contextual
associations among events, undergoes preferential degradation in aging and
various neuropsychiatric disorders. Memory storage of temporal and contextual
associations is known to rely on hippocampal N-methyl-D-aspartate receptor
(NMDAR)-dependent synaptic plasticity, which depends ex vivo on dynamic
organization of surface NMDARs. Whether NMDAR surface trafficking sustains the
formation of associative memory, however, remains unknown.
METHODS: We tested this hypothesis, using single nanoparticle imaging,
electrophysiology, and behavioral approaches, in hippocampal networks challenged
with a potent modulator of NMDAR-dependent synaptic plasticity and memory,
17β-estradiol (E2).
RESULTS: We demonstrate that E2 modulates NMDAR surface trafficking, a necessary
condition for E2-induced potentiation at hippocampal cornu ammonis 1 synapses.
Strikingly, cornu ammonis 1 NMDAR surface trafficking controls basal and
E2-enhanced mnemonic retention of temporal, but not contextual, associations.
CONCLUSIONS: NMDAR surface trafficking and its modulation by the sex hormone E2
is a cellular mechanism critical for a major component of episodic memory,
opening a new and noncanonical research avenue in the physiopathology of
cognition.
Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All
rights reserved.
DOI: 10.1016/j.biopsych.2015.07.017
PMID: 26321020 [Indexed for MEDLINE]