Teashirt 3 Regulates Development of Neurons Involved in Both Respiratory Rhythm and Airflow Control

X. Caubit, M. Thoby-Brisson, N. Voituron, P. Filippi, M. Bevengut, H. Faralli, S. Zanella, G. Fortin, G. Hilaire, L. Fasano
Journal of Neuroscience. 2010-07-14; 30(28): 9465-9476
DOI: 10.1523/jneurosci.1765-10.2010

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1. J Neurosci. 2010 Jul 14;30(28):9465-76. doi: 10.1523/JNEUROSCI.1765-10.2010.

Teashirt 3 regulates development of neurons involved in both respiratory rhythm
and airflow control.

Caubit X(1), Thoby-Brisson M, Voituron N, Filippi P, Bévengut M, Faralli H,
Zanella S, Fortin G, Hilaire G, Fasano L.

Author information:
(1)Unité Mixte de Recherche (UMR) 6216, Centre National de la Recherche
Scientifique (CNRS), Université de la Méditerranée, Institut de Biologie du
Développement de Marseille Luminy, Parc Scientifique de Luminy, Marseille Cedex
9, France.

Neonatal breathing in mammals involves multiple neuronal circuits, but its
genetic basis remains unclear. Mice deficient for the zinc finger protein
Teashirt 3 (TSHZ3) fail to breathe and die at birth. Tshz3 is expressed in
multiple areas of the brainstem involved in respiration, including the
pre-Bötzinger complex (preBötC), the embryonic parafacial respiratory group
(e-pF), and cranial motoneurons that control the upper airways. Tshz3
inactivation led to pronounced cell death of motoneurons in the nucleus ambiguus
and induced strong alterations of rhythmogenesis in the e-pF oscillator. In
contrast, the preBötC oscillator appeared to be unaffected. These deficits result
in impaired upper airway function, abnormal central respiratory rhythm
generation, and altered responses to pH changes. Thus, a single gene, Tshz3,
controls the development of diverse components of the circuitry required for

DOI: 10.1523/JNEUROSCI.1765-10.2010
PMCID: PMC6632443
PMID: 20631175 [Indexed for MEDLINE]

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