Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice

A. Delprato, B. Bonheur, M.-P. Algéo, P. Rosay, L. Lu, R. W. Williams, W. E. Crusio
Genes, Brain and Behavior. 2015-11-01; 14(8): 591-606
DOI: 10.1111/gbb.12259

PubMed
Read on PubMed



1. Genes Brain Behav. 2015 Nov;14(8):591-606. doi: 10.1111/gbb.12259. Epub 2015 Nov
8.

Systems genetic analysis of hippocampal neuroanatomy and spatial learning in
mice.

Delprato A(1)(2)(3), Bonheur B(1)(2), Algéo MP(1)(2), Rosay P(1)(2), Lu L(4),
Williams RW(4), Crusio WE(1)(2).

Author information:
(1)University of Bordeaux, Institut de Neurosciences Cognitives et Intégratives
d’Aquitaine, Pessac, France.
(2)CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine,
Pessac, France.
(3)BioScience Project, Wakefield, MA, USA.
(4)Department of Genetics, Genomics and Informatics, University of Tennessee
Health Sciences Center, Memphis, TN, USA.

Variation in hippocampal neuroanatomy correlates well with spatial learning
ability in mice. Here, we have studied both hippocampal neuroanatomy and behavior
in 53 isogenic BXD recombinant strains derived from C57BL/6J and DBA/2J parents.
A combination of experimental, neuroinformatic and systems genetics methods was
used to test the genetic bases of variation and covariation among traits. Data
were collected on seven hippocampal subregions in CA3 and CA4 after testing
spatial memory in an eight-arm radial maze task. Quantitative trait loci were
identified for hippocampal structure, including the areas of the intra- and
infrapyramidal mossy fibers (IIPMFs), stratum radiatum and stratum pyramidale,
and for a spatial learning parameter, error rate. We identified multiple loci and
gene variants linked to either structural differences or behavior. Gpc4 and Tenm2
are strong candidate genes that may modulate IIPMF areas. Analysis of gene
expression networks and trait correlations highlight several processes
influencing morphometrical variation and spatial learning.

© 2015 John Wiley & Sons Ltd and International Behavioural and Neural Genetics
Society.

DOI: 10.1111/gbb.12259
PMCID: PMC4837474
PMID: 26449520 [Indexed for MEDLINE]

Know more about