Super-resolution links vinculin localization to function in focal adhesions.
1. Nat Cell Biol. 2015 Jul;17(7):845-7. doi: 10.1038/ncb3196.
Super-resolution links vinculin localization to function in focal adhesions.
Giannone G(1).
Author information:
(1)Univ. Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297,
F-33000 Bordeaux, France and CNRS, Interdisciplinary Institute for Neuroscience,
UMR 5297, F-33000 Bordeaux, France.
Comment on
Nat Cell Biol. 2015 Jul;17(7):880-92.
Integrin-based focal adhesions integrate biochemical and biomechanical signals
from the extracellular matrix and the actin cytoskeleton. The combination of
three-dimensional super-resolution imaging and loss- or gain-of-function protein
mutants now links the nanoscale dynamic localization of proteins to their
activation and function within focal adhesions.
DOI: 10.1038/ncb3196
PMID: 26123111 [Indexed for MEDLINE]