Subthalamic stimulation increases striatal tyrosine hydroxylase phosphorylation
NeuroReport. 2008-01-01; 19(2): 179-182
Read on PubMed
1. Neuroreport. 2008 Jan 22;19(2):179-82. doi: 10.1097/WNR.0b013e3282f417b4.
Subthalamic stimulation increases striatal tyrosine hydroxylase phosphorylation.
Reese R(1), Winter C, Nadjar A, Harnack D, Morgenstern R, Kupsch A, Bezard E,
(1)CNRS UMR 5227, Bordeaux, France.
Subthalamic stimulation enhances striatal tyrosine hydroxylase activity, which is
regulated by phosphorylation at different serine residues. Western blotting was
performed to investigate phosphorylation at the serine residues 19, 31 and 40 in
striatal tissue of rats that had received subthalamic stimulation or sham
stimulation for 2 h. In animals that were killed directly after stimulation, the
tyrosine hydroxylase protein content was unchanged, whereas phosphorylation at
the serine residue 19 was increased and phosphorylation at the serine residues 31
and 40 tended to be higher compared with controls. By contrast, tyrosine
hydroxylase protein content and phosphorylation were similar in rats that were
killed 24 h after stimulation. Our results suggest that subthalamic stimulation
may increase tyrosine hydroxylase activity via increased phosphorylation.
PMID: 18185104 [Indexed for MEDLINE]