Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways.
Trends in Cell Biology. 2006-04-01; 16(4): 213-223
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1. Trends Cell Biol. 2006 Apr;16(4):213-23. Epub 2006 Mar 10.
Substrate rigidity and force define form through tyrosine phosphatase and kinase
Giannone G(1), Sheetz MP.
(1)Department of Biological Sciences, Columbia University, New York, NY 10027,
Cell forces define cell morphology, alterations in which are caused by tyrosine
kinase and phosphatase mutations, which implies a causal linkage. Recent studies
have shown that phosphotyrosine signaling is involved in force sensing for cells
on flat surfaces. Early force-dependent activation of Src family kinases by
phosphatases or cytoskeleton stretch leads to the activation of downstream
signaling. In addition, force generation by cells depends on a feedback mechanism
between matrix rigidity or force generation and myosin contractility. Components
of the force-sensing pathway are linked to the integrin-cytoskeleton complex at
sites of force application and serve as scaffolds for signaling processes. Thus,
early events in force detection are mechanically induced cytoskeletal changes
that result in biochemical signals to mechanoresponsive pathways that then
regulate cell form.
PMID: 16529933 [Indexed for MEDLINE]