Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking.

Frédéric Ambroggi, Marc Turiault, Aude Milet, Véronique Deroche-Gamonet, Sébastien Parnaudeau, Eric Balado, Jacques Barik, Rixt van der Veen, Grégoire Maroteaux, Thomas Lemberger, Günther Schütz, Monique Lazar, Michela Marinelli, Pier Vincenzo Piazza, François Tronche
Nat Neurosci. 2009-02-22; 12(3): 247-249
DOI: 10.1038/nn.2282


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1. Nat Neurosci. 2009 Mar;12(3):247-9. doi: 10.1038/nn.2282. Epub 2009 Feb 22.

Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons
facilitates cocaine seeking.

Ambroggi F(1), Turiault M, Milet A, Deroche-Gamonet V, Parnaudeau S, Balado E,
Barik J, van der Veen R, Maroteaux G, Lemberger T, Schütz G, Lazar M, Marinelli
M, Piazza PV, Tronche F.

Author information:
(1)INSERM U862, NeuroCenter Magendie, Pathophysiology of Addiction, 147 Rue Léo
Saignat, 33077 Bordeaux Cedex, France.

The glucocorticoid receptor is a ubiquitous transcription factor mediating
adaptation to environmental challenges and stress. Selective Nr3c1 (the
glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons
expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly
decreased the motivation of mice to self-administer cocaine, dopamine cell firing
and the control exerted by dopaminoceptive neurons on dopamine cell firing
activity. In contrast, anxiety was unaffected, indicating that glucocorticoid
receptors modify a number of behavioral disorders through different neuronal
populations.

DOI: 10.1038/nn.2282
PMID: 19234455 [Indexed for MEDLINE]

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