SPG3A is the most frequent cause of hereditary spastic paraplegia with onset before age 10 years.
Neurology. 2006-01-09; 66(1): 112-114
DOI: 10.1212/01.wnl.0000191390.20564.8e
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1. Neurology. 2006 Jan 10;66(1):112-4.
SPG3A is the most frequent cause of hereditary spastic paraplegia with onset
before age 10 years.
Namekawa M(1), Ribai P, Nelson I, Forlani S, Fellmann F, Goizet C, Depienne C,
Stevanin G, Ruberg M, Dürr A, Brice A.
Author information:
(1)INSERM U679 (former 289), Federative Institute for Neuroscience Research
(IFR70), Salpêtrière Hospital, Paris, France.
Seven families with six different SPG3A mutations were identified among 106 with
autosomal dominant hereditary spastic paraplegia (HSP). Two mutations were novel
(T162P, C375R). SPG3A was twice as frequent as SPG4 in patients with onset before
age 10 years (31.8%). Later onset was not observed. The phenotype was pure HSP,
but disease duration was longer than in non-SPG3A/SPG4 patients, leading
ultimately to greater handicap.
DOI: 10.1212/01.wnl.0000191390.20564.8e
PMID: 16401858 [Indexed for MEDLINE]