Social behavior deficits in the Fmr1 mutant mouse

Yann S. Mineur, Linh X. Huynh, Wim E. Crusio
Behavioural Brain Research. 2006-03-01; 168(1): 172-175
DOI: 10.1016/j.bbr.2005.11.004

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1. Behav Brain Res. 2006 Mar 15;168(1):172-5. Epub 2005 Dec 15.

Social behavior deficits in the Fmr1 mutant mouse.

Mineur YS(1), Huynh LX, Crusio WE.

Author information:
(1)Brudnick Neuropsychiatric Research Institute, University of Massachusetts
Medical School, Worcester, MA, USA.

Mice exhibiting deficits in social behavior may provide valuable models for
autistic-like behavioral problems. We tested social interactions in male mice
from three inbred strains: C57BL/6J (B6), BALB/cJ (C) and DBA/2J (D2). All three
strains showed gradual habituation of the number of social interactions with an
ovariectomized female over four subsequent 2min sessions, returning to initial
levels when presented with another stimulus mouse. Next, we studied males with a
knockout mutation in the Fmr1 gene on a B6 background. KO animals showed strongly
reduced levels of social interaction, which were about similar as those of
habituated controls. This social behavior deficit suggests that Fmr1 KO mice
could possibly be used as models for autistic behaviors.

DOI: 10.1016/j.bbr.2005.11.004
PMID: 16343653 [Indexed for MEDLINE]

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