Self-modulation of neocortical pyramidal neurons by endocannabinoids.

Silvia Marinelli, Simone Pacioni, Astrid Cannich, Giovanni Marsicano, Alberto Bacci
Nat Neurosci. 2009-11-15; 12(12): 1488-1490
DOI: 10.1038/nn.2430

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1. Nat Neurosci. 2009 Dec;12(12):1488-90. doi: 10.1038/nn.2430. Epub 2009 Nov 15.

Self-modulation of neocortical pyramidal neurons by endocannabinoids.

Marinelli S(1), Pacioni S, Cannich A, Marsicano G, Bacci A.

Author information:
(1)European Brain Research Institute, Rome, Italy.

Control of pyramidal neuron excitability is vital for the functioning of the
neocortex. Somatodendritic slow self-inhibition (SSI) allows inhibitory neurons
to regulate their own activity, but the existence of similar mechanisms in
excitatory cells has not been shown. We found that in rodents endocannabinoids
mediated SSI and long-term modulation of inhibitory connections in layer 2/3
pyramidal neurons with a distinct dendritic morphology, suggesting that a
glutamatergic network in cortical circuits is self-regulated.

DOI: 10.1038/nn.2430
PMID: 19915567 [Indexed for MEDLINE]

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