Schwannian crystalline-like inclusions bodies (Fardeau-Engel bodies) revisited in peripheral neuropathies.
Ultrastructural Pathology. 2002-01-01; 26(1): 9-13
DOI: 10.1080/01913120252934279
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1. Ultrastruct Pathol. 2002 Jan-Feb;26(1):9-13. doi: 10.1080/01913120252934279.
Schwannian crystalline-like inclusions bodies (Fardeau-Engel bodies) revisited
in peripheral neuropathies.
Vital C(1), Bouillot S, Canron MH, Vital A.
Author information:
(1)Neuropathology Department, Victor Segalen University, Bordeaux, France.
In 1969, Fardeau and Engel described polygonal organelles containing
crystalline-like structures located in the Schwann cell cytoplasm of
unmyelinated fibers. Such inclusions were reported in various conditions, mainly
with axonal lesions. They were also reported in a few cases of peripheral
neuropathy associated with primary mitochondriopathy. Although they are
surrounded by a double membrane, their mitochondrial origin is not definitely
proven. Their significance remains obscure but they deserve to be better known
as Fardeau-Engel bodies, so as not to be mistaken with mitochondrial crystalline
inclusions, which are frequently observed in patients with ragged-red fibers in
muscle.
DOI: 10.1080/01913120252934279
PMID: 12028653 [Indexed for MEDLINE]