Resting-state fMRI changes in Alzheimer’s disease and mild cognitive impairment
Neurobiology of Aging. 2012-09-01; 33(9): 2018-2028
DOI: 10.1016/j.neurobiolaging.2011.07.003
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1. Neurobiol Aging. 2012 Sep;33(9):2018-28. doi:
10.1016/j.neurobiolaging.2011.07.003. Epub 2011 Aug 20.
Resting-state fMRI changes in Alzheimer’s disease and mild cognitive impairment.
Binnewijzend MA(1), Schoonheim MM, Sanz-Arigita E, Wink AM, van der Flier WM,
Tolboom N, Adriaanse SM, Damoiseaux JS, Scheltens P, van Berckel BN, Barkhof F.
Author information:
(1)Department of Radiology, VU University Medical Center, Amsterdam, The
Netherlands.
Regional functional connectivity (FC) of 39 patients with Alzheimer’s disease
(AD), 23 patients with mild cognitive impairment (MCI), and 43 healthy elderly
controls was studied using resting-state functional magnetic resonance imaging
(rs-fMRI). After a mean follow-up of 2.8 ± 1.9 years, 7 MCI patients converted to
AD, while 14 patients remained cognitively stable. Resting-state functional
magnetic resonance imaging scans were analyzed using independent component
analysis (ICA), followed by a “dual-regression” technique to create and compare
subject-specific maps of each independent spatiotemporal component, correcting
for age, sex, and gray matter atrophy. AD patients displayed lower FC within the
default-mode network (DMN) in the precuneus and posterior cingulate cortex
compared with controls, independent of cortical atrophy. Regional FC values of
MCI patients were numerically in between AD patients and controls, but only the
difference between AD and stable MCI patients was statistically significant.
Correlation with cognitive dysfunction demonstrated the clinical relevance of FC
changes within the DMN. In conclusion, clinically relevant decreased FC within
the DMN was observed in AD.
Copyright © 2012 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neurobiolaging.2011.07.003
PMID: 21862179 [Indexed for MEDLINE]