Responses of substantia nigra pars reticulata and globus pallidus complex to high frequency stimulation of the subthalamic nucleus in rats: electrophysiological data
Neuroscience Letters. 1995-04-01; 189(2): 77-80
DOI: 10.1016/0304-3940(95)11455-6
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1. Neurosci Lett. 1995 Apr 14;189(2):77-80. doi: 10.1016/0304-3940(95)11455-6.
Responses of substantia nigra pars reticulata and globus pallidus complex to
high frequency stimulation of the subthalamic nucleus in rats:
electrophysiological data.
Benazzouz A(1), Piallat B, Pollak P, Benabid AL.
Author information:
(1)Laboratoire de Neurobiophysique, UJFG, INSERM U.318, Centre Hospitalier
Universitaire de Grenoble, France.
High frequency stimulation of the subthalamic nucleus (STN-HFS) has been shown
to reverse parkinsonian motor symptoms in
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. We have
studied the effect of STN-HFS on the spontaneous activity of the substantia
nigra pars reticulata (SNr), entopeduncular nucleus (EP) and globus pallidus
(GP) in rats. STN-HFS induced a decrease in activity of 91% of SNr cells, a
suppression of activity in 80% of EP cells and an activation of 100% of GP
recorded cells. These results show that STN-HFS exerts an inhibitory influence
on the basal ganglia output structures similar to that obtained by STN lesion.
DOI: 10.1016/0304-3940(95)11455-6
PMID: 7609923 [Indexed for MEDLINE]