REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP

Pascal Ravassard, Al Mahdy Hamieh, Mickaël Antoine Joseph, Nicolas Fraize, Paul-Antoine Libourel, Léa Lebarillier, Sébastien Arthaud, Claire Meissirel, Monique Touret, Gaël Malleret, Paul-Antoine Salin
Cereb. Cortex. 2015-01-13; 26(4): 1488-1500
DOI: 10.1093/cercor/bhu310

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1. Cereb Cortex. 2016 Apr;26(4):1488-1500. doi: 10.1093/cercor/bhu310. Epub 2015 Jan
13.

REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional
Memory and LTP.

Ravassard P(1)(2)(3)(4), Hamieh AM(1)(2)(3)(5), Joseph MA(1)(2)(3), Fraize
N(1)(2)(3), Libourel PA(1)(2)(3), Lebarillier L(1)(2)(3), Arthaud S(1)(2)(3),
Meissirel C(1)(3)(6), Touret M(1)(3)(6), Malleret G(1)(2)(3), Salin PA(1)(2)(3).

Author information:
(1)Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche
5292 ; Institut National de la Santé et de la Recherche Médicale (INSERM), Unité
1028, Lyon Cedex 08, France.
(2)Physiopathology of the Sleep Neuronal Networks, Lyon Neuroscience Research
Center, F-69008 Lyon, France.
(3)University Lyon 1, F-69000 Lyon, France.
(4)Current address: Department of Physics and Astronomy, Department of Neurology,
University of California, Los Angeles, CA 90095, USA.
(5)Current address: INSERM U1107, UdA Neuro-Dol Equipe Pharmacologie Fondamentale
et Clinique de la Douleur, Facultés de Médecine et de Pharmacie, 28 Place
Henri-Dunant BP38, 63001 Clermont-Ferrand, France.
(6)Neuro-oncology and Neuro-inflammation, Lyon Neuroscience Research Center,
F-69000 Lyon, France.

Prolonged rapid-eye-movement (REM) sleep deprivation has long been used to study
the role of REM sleep in learning and memory processes. However, this method
potentially induces stress and fatigue that may directly affect cognitive
functions. Here, by using a short-term and nonstressful REM sleep deprivation
(RSD) method we assessed in rats the bidirectional influence of reduced and
increased REM sleep amount on hippocampal-dependent emotional memory and
plasticity. Our results indicate that 4 h RSD impaired consolidation of
contextual fear conditioning (CFC) and induction of long-term potentiation (LTP),
while decreasing density of Egr1/Zif268-expressing neurons in the CA1 region of
the dorsal hippocampus. LTP and Egr1 expression were not affected in ventral CA1.
Conversely, an increase in REM sleep restores and further facilitates CFC
consolidation and LTP induction, and also increases Egr1 expression in dorsal
CA1. Moreover, CFC consolidation, Egr1 neuron density, and LTP amplitude in
dorsal CA1 show a positive correlation with REM sleep amount. Altogether, these
results indicate that mild changes in REM sleep amount bidirectionally affect
memory and synaptic plasticity mechanisms occurring in the CA1 area of the dorsal
hippocampus.

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DOI: 10.1093/cercor/bhu310
PMID: 25585510 [Indexed for MEDLINE]

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