Relationship between anxiety disorders and opiate dependence- A systematic review of the literature. Implications for diagnosis and treatment

Melina Fatséas, Cécile Denis, Estelle Lavie, Marc Auriacombe
Journal of Substance Abuse Treatment. 2010-04-01; 38(3): 220-230
DOI: 10.1016/j.jsat.2009.12.003

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1. J Subst Abuse Treat. 2010 Apr;38(3):220-30. doi: 10.1016/j.jsat.2009.12.003. Epub
2010 Feb 8.

Relationship between anxiety disorders and opiate dependence–a systematic review
of the literature: implications for diagnosis and treatment.

Fatséas M(1), Denis C, Lavie E, Auriacombe M.

Author information:
(1)Laboratoire de Psychiatrie and EA 4139, Université Victor Segalen Bordeaux 2,
INSERM-IFR-99, Bordeaux, France (EU).

Our objective was to evaluate the prevalence and temporal sequence of
co-occurrence of anxiety disorders with opiate dependence in order to better
define the relationship between these two disorders and to improve diagnosis and
treatment. The search used Medline and Toxibase up to January 1, 2009, and was
based on a systematic review method. Eighteen studies were found. Prevalence of
anxiety disorders assessed by Diagnostic and Statistical Manual of Mental
Disorders, Fourth Edition (DSM-IV) criteria was high in opiate-dependent treated
persons (lifetime prevalence ranged from 26% to 35%). Among anxiety disorders,
phobic disorders have been shown to often precede the onset of opiate dependence.
The identification of substance-induced versus independent anxiety disorder has
important treatment implication. The monitoring of anxiety symptoms after several
weeks of abstinence may allow physicians to determine the relationship between
dependence and anxiety and make a reliable diagnosis of any initial anxious
disorder. Specific management of anxiety disorder may then be used.

Copyright 2010 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.jsat.2009.12.003
PMID: 20116963 [Indexed for MEDLINE]

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