Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation.
Psychol. Med.. 2010-10-20; 41(07): 1517-1528
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1. Psychol Med. 2011 Jul;41(7):1517-28. doi: 10.1017/S0033291710001984. Epub 2010
Relationship between adiposity, emotional status and eating behaviour in obese
women: role of inflammation.
Capuron L(1), Poitou C, Machaux-Tholliez D, Frochot V, Bouillot JL, Basdevant A,
Layé S, Clément K.
(1)Laboratory of Psychoneuroimmunology, Nutrition and Genetics (PSYNUGEN),
University Victor Segalen Bordeaux 2, INRA 1286, CNRS 5226, 146 rue Léo Saignat,
Bordeaux, F-33076 France.
BACKGROUND: Obesity is characterized by chronic low-grade inflammation that may
lead to emotional distress and behavioural symptoms. This study assessed the
relationship between adiposity, low-grade inflammation, eating behaviour and
emotional status in obese women awaiting gastric surgery and investigated the
effects of surgery-induced weight loss on this relationship.
METHOD: A total of 101 women with severe or morbid obesity awaiting gastric
surgery were recruited. Assessments were performed before and at 1 year
post-surgery and included the measurement of neuroticism and extraversion using
the revised Neuroticism-Extraversion-Openness personality inventory (NEO-PI-R)
and eating behaviour using the Three-Factor Eating Questionnaire (TFEQ). Blood
samples were collected for the measurement of serum inflammatory markers
[interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP)] and adipokines
RESULTS: At baseline, body mass index (BMI) was positively correlated with
inflammatory markers and adipokines. Regression analyses adjusting for age and
diabetes revealed that baseline concentrations of IL-6 and hsCRP were associated
with the depression and anxiety facets of neuroticism, with higher inflammation
predicting higher anxiety and depression. This association remained significant
after adjusting for BMI. Gastric surgery induced significant weight loss, which
correlated with reduced inflammation. After controlling for BMI variations,
decreases in inflammatory markers, notably hsCRP, were associated with reduced
anxiety and TFEQ-cognitive restraint scores.
CONCLUSIONS: These findings indicate strong associations between adiposity,
inflammation and affectivity in obese subjects and show that surgery-induced
weight loss is associated concomitantly with reduced inflammation and adipokines
and with significant improvement in emotional status and eating behaviour.
Inflammatory status appears to represent an important mediator of emotional
distress and psychological characteristics of obese individuals.
PMID: 20961476 [Indexed for MEDLINE]