Reciprocal interaction between monoaminergic systems and the pedunculopontine nucleus: Implication in the mechanism of L-DOPA

Giuseppe Di Giovanni, Abdeslam Chagraoui, Emilie Puginier, Salvatore Galati, Philippe De Deurwaerdère
Neurobiology of Disease. 2019-08-01; 128: 9-18
DOI: 10.1016/j.nbd.2018.08.014

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Di Giovanni G(1), Chagraoui A(2), Puginier E(2), Galati S(3), De Deurwaerdère P(4).

Author information:
(1)Department of Physiology & Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta; Neuroscience Division, School of Biosciences, Cardiff University, Cardiff, UK.
(2)Normandie Univ, UNIROUEN, INSERM, U1239, CHU Rouen, Neuronal and Neuroendocrine Differentiation and Communication Laboratory, Institute for Research and Innovation in Biomedicine of Normandy (IRIB), Rouen, France; Department of Medical Biochemistry, Rouen University Hospital, Rouen, France.
(3)Parkinson and movement Disorders Center Neurocenter of Southern Switzerland, Ospedale Civico di Lugano, Lugano, Switzerland.
(4)Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5287), 146 rue Léo Saignat, B.P.281, F-33000 Bordeaux Cedex, France.

The pedunculopontine nucleus (PPN) is part of the mesencephalic locomotor region
(MLR) and has been involved in the control of gait, posture, locomotion, sleep,
and arousal. It likely participates in some motor and non-motor symptoms of
Parkinson’s disease and is regularly proposed as a surgical target to ameliorate
gait, posture and sleep disorders in Parkinsonian patients. The PPN overlaps with
the monoaminergic systems including dopamine, serotonin and noradrenaline in the
modulation of the above-mentioned functions. All these systems are involved in
Parkinson’s disease and the mechanism of the anti-Parkinsonian agents, mostly
L-DOPA. This suggests that PPN interacts with monoaminergic neurons and vice
versa. Some evidence indicates that the PPN sends cholinergic, glutamatergic and
even gabaergic inputs to mesencephalic dopaminergic cells, with the data
regarding serotonergic or noradrenergic cells being less well known. Similarly,
the control exerted by the PPN on dopaminergic neurons, is multiple and complex,
and more extensively explored than the other monoaminergic systems. The data on
the influence of monoaminergic systems on PPN neuron activity are rather scarce.
While there is evidence that the PPN influences the therapeutic response of
L-DOPA, it is still difficult to discerne the reciprocal action of the PPN and
monoaminergic systems in this action. Additional data are required to better
understand the functional organization of monoaminergic inputs to the MLR
including the PPN to get a clearer picture of their interaction.

Copyright © 2018 Elsevier Inc. All rights reserved.


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